Effects of Heat Clearing and Stasis Resolving Method on PTS,Inflammatory Factors and T-lymphocyte Subsets in Peripheral Blood of URM Patients with Suppressed Internal Heat  

作　　者：Fenqin ZHAO Jieying LIU Yan ZHAO Yajiao GOU Zhixia HU 

机构地区：[1]Medical College of Integrated Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China

出　　处：《Medicinal Plant》2022年第4期34-38,共5页药用植物：英文版

基　　金：Supported by National Natural Science Foundation of China(81760806);Project of Traditional Chinese Medicine Administration of Gansu Province(GZK-2019-28);Innovation Ability Improvement Project of Higher Education Institutions of Gansu Province(2019B-103)。

摘　　要：[Objectives]To explore the effects of heat clearing and stasis resolving method on prethrombotic state,inflammatory factors and T-lymphocyte subsets in peripheral blood of unexplained recurrent miscarriage(URM)patients with suppressed internal heat.[Methods]Thirty cases of URM patients with suppressed internal heat and 30 normal women were collected,and characteristics of changes in peripheral serum D-dimer(D-D),fibrin degradation product(FDP),fibrinogen(FIB),IL-6,IL-10 and TNF-α,CD,CD,CD,CD,CDlevels were detected.URM patients were treated with traditional Chinese medicine for clearing heat and resolving blood stasis for 3 menstrual cycles,and the changes of indicators before and after treatment were observed.[Results]Compared with normal women,the peripheral serum levels of D-D,IL-6,TNF-αand CDin URM patients with suppressed internal heat were increased(P<0.05),while the IL-10 lymphocyte level was significantly decreased(P<0.05);compared with that before treatment,the contents of D-D,IL-6,TNF-αand CDdecreased after 3 menstrual cycles(P<0.05),while the contents of IL-10 and CDT lymphocytes increased significantly(P<0.05).[Conclusions]The heat clearing heat and stasis resolving method can effectively improve the prethrombotic state of URM,and the action mechanism may be related to the regulation of immune and peripheral blood inflammatory factors.

关 键 词：Unexplained recurrent miscarriage(URM) Suppressed internal heat type Prethrombotic state(PTS) Heat clearing and stasis resolving Inflammatory factors T-lymphocyte subsets 

分 类 号：R271.9[医药卫生—中西医结合]