炒稻芽配方颗粒质量控制方法研究  

Study on Quality Control Method of Fried Rice Bud Formula Granules

作　　者：李蕊 张志强 高扬 Li Rui;Zhang Zhiqiang;Gao Yang(Beijing Tcmages Pharmaceutical Co.,Ltd.,Traditional Chinese Medicine Formula Particles Key Technology National United Engineering Research Center,Beijing Chinese Medicinne Formula Particles Engineering Technology Research Center,Beijing 101301,China)

机构地区：[1]北京康仁堂药业有限公司中药配方颗粒关键技术国家地方联合工程研究中心北京市中药配方颗粒工程技术研究中心,北京101301

出　　处：《山东化工》2022年第19期67-74,共8页Shandong Chemical Industry

摘　　要：目的:对炒稻芽配方颗粒的指纹图谱及含量测定方法进行研究。方法:采用高效液相色谱法测定炒稻芽配方颗粒中4-香豆酸的含量,并采用同一方法进行特征图谱及指纹图谱的研究。结果:4-香豆素含量的线性范围为0.003 948 168~0.098 704 2 mg/mL(r^(2)=1.000 0),平均回收率为98.8%;图谱中共标记6个共有峰,其中5号峰4-香豆酸峰保留时间适中,峰面积较大,分离度较好,确定为S峰。指纹图谱研究显示15批炒稻芽子配方颗粒相似度良好,均大于0.90。结论:所用方法准确稳定,重复性好,可有效控制炒稻芽配方颗粒的质量。Objective:To study the fingerprint and content determination of fried rice bud formula granules.Methods:The content of 4-coumaric acid in fried rice bud formula granules was determined by HPLC,and the fingerprint was studied by the same method.Results:The linear range of 4-coumarin content was 0.003948168~0.0987042 mg/mL(r^(2)=1.0000),the average recovery was 98.8%.There are 6 common peaks marked in the map.Among them,peak 5,4-coumaric acid peak,with moderate retention time,large peak area and good resolution,is determined as s peak.The fingerprint study showed that the similarity of 15 batches of fried rice sprout formula particles was good,all of which were greater than 0.90.Conclusion:The method is accurate,stable and reproducible,and can effectively control the quality of fried rice bud formula granules.

关 键 词：炒稻芽配方颗粒 指纹图谱 4-香豆酸 含量测定 

分 类 号：TQ460.7[化学工程—制药化工] R283.6[医药卫生—中药学]