乳腺癌术后内分泌治疗患者伴随症状的中医证型分布规律  

Study on the Distribution of TCM Syndrome Types of Concomitant Symptoms in Patients with Breast Cancer After Endocrine Therapy

作　　者：师宇 陈波 谢伟[1] 王斌 陈翱翔[4,5,6,7] 巴东升[2,3] 杨水仙 张心怡 史丽萍 SHI Yu;CHEN Bo;XIE Wei;WANG Bin;CHEN Aoxiang;BA Dongsheng;YANG Shuixian;ZHANG Xinyi;SHI Liping(School of Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;National Clinical Research Center of Chinese Acupuncture and Moxibustion,Tianjin 301617,China;School of Acupuncture&Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center for Cancer,Tianjin 300181,China;Key Laboratory of Cancer Prevention and Therapy,Tianjin 300181,China;Tianjin's Clinical Research Center for Cancer,Tianjin 300181,China;Key Laboratory of Breast Cancer Prevention and Therapy,Tianjin Medical University,Ministry of Education,Tianjin 300181,China)

机构地区：[1]天津中医药大学中医学院,天津301617 [2]国家中医针灸临床医学研究中心,天津301617 [3]天津中医药大学针灸推拿学院,天津301617 [4]天津医科大学肿瘤医院/国家肿瘤临床医学研究中心,天津300181 [5]天津市“肿瘤防治”重点实验室,天津300181 [6]天津市恶性肿瘤临床医学研究中心,天津300181 [7]乳腺癌防治教育部重点实验室,天津300181

出　　处：《中医药导报》2022年第10期145-149,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局标准化项目(ZX2002)。

摘　　要：目的:探讨乳腺癌术后内分泌治疗患者伴随症状的中医证型分布规律,为临床辨证施治提供依据。方法:选取289例乳腺癌术后服用内分泌药物的患者进行横断面调查,获取其四诊信息,通过SPSS 26.0软件进行聚类分析,结合《证素辨证学》中的辨证方法进行证型归纳;依据患者主诉,通过《证素辨证学》归纳主要证型。结果:基于聚类结果进行证型归类,共有气虚湿阻证、心阴亏虚证、肝郁气滞证和肾阴亏虚证4个证型;基于患者主诉,关节疼痛的患者以筋骨湿阻证、筋骨寒湿证和筋骨血瘀证为主,潮热汗出的患者以肝阴虚证为主,不寐的患者以心神阴虚证为主,乏力的患者以脾阳虚证为主。结论:依据患者主诉,乳腺癌术后内分泌治疗患者伴随症状的中医证型分为筋骨湿阻证、筋骨寒湿证、筋骨血瘀证、肝阴虚证、心神阴虚证和脾阳虚证。乳腺癌术后内分泌治疗患者的伴随症状繁多,病因复杂,临床辨证须依据患者的主诉分清主次,精准辨证。Objective:To explore the distribution of TCM syndrome types of adverse reactions in patients with breast cancer after endocrine therapy,and to provide basis for clinical syndrome differentiation and treatment.Methods:A cross-sectional survey was conducted on 289 patients who took endocrine drugs after breast cancer surgery to obtain the information of the four diagnoses.Cluster analysis was performed by SPSS 26.0 software and syndrome differentiation was performed to summarize syndrome types.According to the chief complaint of the patient,the syndrome differentiation of each patient was classified according to the syndrome differentiation of syndrome elements,and the main syndrome types were summarized.Results:The clustering results were classified into four syndrome types,namely,Qi deficiency and dampness resistance syndrome,heart-yin deficiency syndrome,liver stagnation and Qi Stagnation syndrome and kidney-yin deficiency syndrome.According to the chief complaint of patients,the patients with arthralgia were mainly the syndrome of dampness of muscles and bones,cold dampness of muscles and bones and blood stasis of muscles and bones.The patients with hot flushes and sweating were mainly liver-yin deficiency syndrome.The patients with insomnia mainly focus on heart-yin deficiency syndrome.The deficiency of spleen-yang was the main symptom in patients with fatigue.Conclusion:According to the patients'complaints,the TCM syndromes associated with endocrine therapy after breast cancer were divided into dampness blocking syndrome of muscles and bones,cold dampness syndrome of muscles and bones,blood stasis syndrome of muscles and bones,liver-yin deficiency syndrome,heart-yin deficiency syndrome and spleen yang deficiency syndrome.The concomitant symptoms of patients undergoing endocrine therapy after breast cancer surgery are numerous and the etiology is complex.Clinical syndrome differentiation needs to distinguish the primary and secondary according to the chief complaints of patients and make accurate syndrome diff

关 键 词：乳腺癌 内分泌治疗 伴随症状 中医证型 分布规律 

分 类 号：R273.379[医药卫生—中西医结合]