基于数据挖掘的藏药喜马拉雅紫茉莉组方配伍规律研究  

Study on Compatibility Law of Tibetan Medicinal Material Ximalaya Zimoli(Himalayan purple jasmine)based on Data Mining

作　　者：卓玛措毛 娘格才让 格拉措 多杰仁青 才让南加 Zhuoma Cuomao;Niangge Cairang;Gelacuo;Duojie Renqing;Cairang Nanjia(University of Tibetan Medicine,Lhasa Tibet 850000,China)

机构地区：[1]西藏藏医药大学,西藏拉萨850000

出　　处：《中医药导报》2022年第10期150-155,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2020年中医学(藏医)博士点建设科研支撑计划项目(BSDJS-20-13);西藏自治区科技计划项目(XZ202001Y0003C)。

摘　　要：目的:运用数据挖掘研究藏药喜马拉雅紫茉莉的组方配伍规律,为临床应用及新药开发提供参考。方法:搜集文献数据,通过Microsoft Excel 2019软件对含有喜马拉雅紫茉莉药方进行整理归类;运用中医传承计算平台(TCMICS 3.0)统计分析高频数药物及核心药物组合、疾病治疗频数及药物“味性化味”规律;通过FP-tree算法对药方中各味藏药间进行关联规则分析,分别设置不同支持度来分析疾病的药方配伍规律。结果:含喜马拉雅紫茉莉药方共129首,与之配伍使用药物有297味,配伍使用频数≥15的藏药33味,≥30的藏药10味,药味以甘、苦、辛为主,三化味中以苦化味与甘化味居多,同时药性以钝、软、凉、温为主。共涉及130种疾病,其中频数较高的为妇科病、寒性肾病、黄水病。通过关联规则分析得出33项常用核心药物组合。支持度、置信度、频数分别为30%、0.97、36的5味药物组合(蒺藜,黄精,天门冬,西藏凹乳芹→喜马拉雅紫茉莉)是藏药五大根散的药物组成。置信度较高的药对组合有蒺藜,白豆蔻→喜马拉雅紫茉莉,黄精,白豆蔻→喜马拉雅紫茉莉;荜茇→喜马拉雅紫茉莉,石榴→喜马拉雅紫茉莉,天门冬,白豆蔻→喜马拉雅紫茉莉;蒺藜→喜马拉雅紫茉莉,黄精→喜马拉雅紫茉莉,天门冬→喜马拉雅紫茉莉的频数较高。结论:通过中医传承辅助平台分析含喜马拉雅紫茉莉药方的常用药物配伍及主治疾病的特点,可知喜马拉雅紫茉莉味甘、性温,以臣药形式辅佐君药,使调“隆”滋补的作用增强,起调节“隆”、祛寒、调和诸药的作用。喜马拉雅紫茉莉与其他药物组合形成的药方,其甘味药最多,以调“隆”滋补为主,多用于治疗妇科病。药方中药性温凉兼用,药味甘苦相辅,符合传统藏药药方中的“味性化味”配伍用药理论。Objective:To study the prescription compatibility of Tibetan medicinal material Ximalaya Zimoli(Himalayan purple jasmine)by data mining,so as to provide reference for clinical application and new drug development.Methods:The literature data were collected and the prescriptions containing Ximalaya Zimoli(Himalayan purple jasmine)were sorted and classified by Microsoft Excel 2019 software.The TCM inheritance computing platform(TCMICS 3.0)was used to statistically analyze the combination of high-frequency drugs and core drugs,the frequency of disease treatment and the"taste of drugs"law.FP-tree algorithm is used to analyze the association rules among various Tibetan medicinal materials in the prescription,and different support degrees are set to analyze the compatibility law of the prescription.Results:There were 129 prescriptions containing Ximalaya Zimoli(Himalayan purple jasmine).There were 297 herbs used in combination with them.There were 33 Tibetan herbs used more than 15 times,and 10 Tibetan medicines with the frequency of use more than 30 times.The herbs were mainly sweet,bitter and pungent.Among the three flavors,bitter and sweet were the most common.At the same time,the medicinal properties were dull,soft,cool and mild.A total of 130 diseases were involved,among which gynecological diseases,cold nephropathy and yellow water disease had a high frequency.Through association rule analysis,33 common core drug combinations were obtained.The five drug combinations[Jili(Tribulus terrestris),Huangjing(Rhizoma polygoni),Tianmendong(Asparagus),Xizang Aoruqin(Tibetan oenanthera glabra)]→Ximalaya Zimoli(Himalayan purple jasmine)with the support,confidence and frequency of 30%,0.97 and 36 respectively are the basic components of Tibetan medicine Wudagen San(五大根散).The drug pair combinations with high confidence are JILI(Tribulus terrestris),Baidou kou(white cardamcm)→Ximalaya Zimoli(Himalayan purple jasmine),Huangjing(Rhizoma polygoni),Baidoukou(white cardamom)→Ximalaya Zimoli(Himalayan purple jasmine),Bib

关 键 词：喜马拉雅紫茉莉 藏药 配伍规律 五大根散 数据挖掘 

分 类 号：R291.404[医药卫生—民族医学]