新型光触发一氧化氮供体的设计与合成  

Design and Synthesis of Novel Phototriggered Nitric Oxide Donor

作　　者：易静雯 刘艾文 黄甜 李贇贇 黄佩 王芹[1] 李玟 张晟瑞[1] YI Jing-wen;LIU Ai-wen;HUANG Tian;LI Yun-yun;HUANG Pei;WANG Qin;LI Wen;ZHANG Sheng-rui(School of Chemistry and Environment Science,Shaanxi University of Technology,Shaanxi Hanzhong 723000,China)

机构地区：[1]陕西理工大学化学与环境科学学院,陕西汉中723000

出　　处：《广州化工》2022年第19期41-43,54,共4页GuangZhou Chemical Industry

基　　金：秦巴生物资源与生态环境国家重点实验室(培育)“市校共建”科研专项(No:SXJ-2103、No:SXJ-2105);陕西理工大学化学与环境科学学院大学生创新创业训练计划项目(No:SLGHX2022006、No:SLGHX2022007)。

摘　　要：含有N-亚硝基推拉体系的染料是一种独特的一氧化氮(NO)供体,光照后,释放NO并伴随着荧光信号升高。本工作中,设计并合成了一种以7-氨基-4-(对甲苯基)-2-(三氟甲基)喹啉为荧光团的新型NO供体(TQ-NO)。黑暗条件下,TQ-NO没有荧光,最大吸收峰在285 nm和366 nm处。而在365 nm紫外光照射后,431 nm处的荧光逐渐增强,285 nm和366 nm处的吸收值逐渐下降,据此可实现对NO释放量的监控。The dye containing N-nitroso push-pull system is a unique nitric oxide(NO) donor.After light exposure, NO is released and the fluorescence signal increases.A new NO donor(TQ-NO) with 7-amino-4-(p-methylphenyl)-2-(trifluoromethyl) quinoline as fluorophore was designed and synthesized.Under dark conditions, TQ-NO had no fluorescence, and the maximum absorption peak was at 285 nm and 366 nm.However, after UV irradiation at 365 nm, the fluorescence at 431 nm was gradually enhanced, and the absorption values at 285 nm and 366 nm were gradually decreased.Accordingly, the release of NO can be monitored.

关 键 词：NO供体 光触发 NO释放 喹啉 

分 类 号：O657.3[理学—分析化学]