7-甲基-3,4-二苯基-1H-异香豆素的合成研究  

Study on Synthesis of 7-methyl-3,4-diphenyl-1H-isochromen-1-one

作　　者：余丽梅 刘奕祯 刘卉[1] 陶李明[1] YU Li-mei;LIU Yi-zhen;LIU Hui;TAO Li-ming(Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds and Application,School of Chemistry and Environmental Science,Xiangnan University,Hunan Chenzhou 423000,China)

机构地区：[1]湘南稀贵金属化合物及其应用湖南省重点实验室,湘南学院化学与环境科学学院,湖南郴州423000

出　　处：《广州化工》2022年第19期52-54,共3页GuangZhou Chemical Industry

基　　金：湖南省自然科学基金项目(No:2021JJ30636);郴州市科技计划项目(No:ZDYF201910);湘南学院科学研究项目(No:2018XJ22)。

摘　　要：碘苯与苯乙炔经Sonogashira交叉偶联反应合成了二苯乙炔,然后二苯乙炔再与苯甲酸通过[4+2]环化反应合成目标产物7-甲基-3,4-二苯基-1 H-异香豆素。反应分两步进行,分别对每一步反应的合成条件进行了优化,产物结构经由NMR分析得以确证,反应收率较高,总产率达到77%,反应条件温和,操作简单而且两步反应的催化体系均可以回收重复使用,反应具有较高的经济性和较好的绿色性。Diphenylethyne was synthesized by sonogashira cross-coupling reaction with iodobenzene and phenylacetylene, then the target product 7-methyl-3,4-diphenyl-1H-isocoumarin was synthesized by [4+2]cyclization reaction between diphenylacetylene and benzoic acid.The reaction was carried out in two steps, the synthesis conditions of each step were optimized.The product structures were confirmed by NMR.The reaction yield was high, the reaction conditions were mild and the catalytic system could be recycled and reused.The reaction had higher economy and better green.

关 键 词：Sonogashira交叉偶联反应 环化反应 二苯乙炔 7-甲基-3 4-二苯基-1H-异香豆素 

分 类 号：TQ914.1[化学工程]