玉米醇溶蛋白/阿维菌素纳米制剂的制备与性能  

Preparation and Properties of Zein/Avermectin Nano Formulation

作　　者：陈树茂[1] 李梓泳 何培浩 周红军[2] 周新华[2] CHEN Shu-mao;LI Zi-yong;HE Pei-hao;ZHOU Hong-jun;ZHOU Xin-hua(Shenzhen Noposion Agrochemicals Co.,Ltd.,Guangdong Shenzhen 518102;Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution,School of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Engineering,Guangdong Guangzhou 510225,China)

机构地区：[1]深圳诺普信农化股份有限公司,广东深圳518102 [2]仲恺农业工程学院化学化工学院,广东省普通高校农用绿色精细化学品重点实验室,广东广州510225

出　　处：《广州化工》2022年第19期69-72,78,共5页GuangZhou Chemical Industry

基　　金：广东省农业产业技术体系共性关键技术(农业纳米)创新团队(No:2019KJ140)。

摘　　要：阿维菌素易光解,通过包封以提高其利用效率。利用玉米醇溶蛋白的疏水特性和自组装的特点,通过反溶剂法制备玉米醇溶蛋白/阿维菌素纳米制剂。通过单因素试验确定粒径DLS为83.72 nm的最小载药粒子(AVM@Zein)的制备条件,其包封率为48.45%,在扫描电镜下为球形颗粒;AVM@Zein在包菜和黄瓜叶面的滞留量分别为21 mg/cm^(2)和28 mg/cm^(2);AVM@Zein具有明显的氧化还原刺激响应释放性能,抗紫外线降解性能显著提高,提高了原药的杀虫活性,提高了阿维菌素的利用率。Abamectin is easily photodegradable,and its wtilization afficieny was improved by encapsulation.Zein/avermectin nanoformulations were prepared by anti-solvent method using the hydrophobic properties and self-assembly characteristics of zein.The preparation conditions of the smallest drug-loaded particles(AVM@Zein)with a particle size DLS of 83.72 nm were determined by single factor experiments.The encapsulation efficiency was 48.45%,and they were spherical particles under scanning electron microscope.The retention of cucumber leaves was 21 mg/cm^(2) and 28 mg/cm^(2),respectively.AVM@Zein had obvious redox stimuli-responsive release performance,significantly improved anti-ultraviolet degradation performance,improved the insecticidal activity of the original drug,and improved the utilization of avermectin.

关 键 词：玉米醇溶蛋白 阿维菌素 缓释 抗紫外 

分 类 号：TQ450.6[化学工程—农药化工]