基于拉曼条形码的呼出气体中疾病标志物快速检测方法  

Fast Detection of Biomarker in Exhaled Breath Based on Surface-enhanced Raman Scattering Barcodes

作　　者：许婧文 宋焱焱 XU Jing-Wen;SONG Yan-Yan(College of Sciences,Northeastern University,Shenyang 114001,China)

机构地区：[1]东北大学理学院,沈阳114001

出　　处：《分析化学》2022年第11期1765-1768,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No 22074013)资助。

摘　　要：呼出气体中的挥发性有机物(VOCs)具有“指纹”特征,可作为疾病标志物用于癌症的早期筛查。表面增强拉曼散射(SERS)光谱具有响应迅速、可抗水分子干扰等优点,将其用于VOCs检测具有独特优势。然而,SERS体系用于呼出气中疾病标志物的检测面临着气体分子迁移率高导致检测灵敏度低和对单一类型组分检测易造成误诊两大挑战。近期,华东师范大学田阳教授研究组开发了具有类海绵状结构的半导体材料作为SERS基底,并利用拉曼条形码技术实现对人呼出气体中多种肺癌标志物的高灵敏快速检测,相关成果发表在Angewandte Chemie-International Edition期刊,该研究为疾病的早期诊断提供了新思路。Volatile organic compounds(VOCs) in exhaled breath have “fingerprint” feature, thus can be used as disease markers for early cancer diagnosis. Surface-enhanced Raman scattering(SERS) has a rapid response speed, and it is anti-interference to water molecules. However, the application of SERS for detection of disease markers in exhaled breath is faced with two major challenges: the low detection sensitivity caused by the high mobility of gas molecules and the high misdiagnosis rate induced by detection of single biomarker. Recently, on Angewandte Chemie-International Edition, Professor TIAN Yang from East China Normal University used Cu-doped p-n heterojunction semiconductor with spongy-like structure as SERS substrate. By combining with Raman barcodes, the proposed SERS platform was applied to detect multiple biomarkers in human exhaled breath simultaneously for diagnosis of lung cancer with high sensitivity, providing a new strategy for the early diagnosis of cancers.

关 键 词：疾病标志物 非入侵检测 表面增强拉曼散射 拉曼条形码 化学增强 

分 类 号：R313[医药卫生—基础医学] O657.37[理学—分析化学]