极速脉搏波技术在糖尿病前期患者颈动脉弹性功能评估中应用价值  

Application value of ultrafast pulse wave velocity technique in the evaluation of carotid artery elasticity in patients with prediabetes

作　　者：孙琳 孙晓枫 余芬[1] 孔曼[2] 刘建新 杨顺实[1] SUN Lin;SUN Xiaofeng;YU Fen;KONG Man;LIU Jianxin;YANG Shunshi(Department of Ultrasound,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430014,China;Department of Laboratory,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430014,China)

机构地区：[1]华中科技大学同济医学院附属武汉市中心医院超声影像科,湖北武汉430014 [2]华中科技大学同济医学院附属武汉市中心医院检验科,湖北武汉430014

出　　处：《医学影像学杂志》2022年第10期1670-1674,共5页Journal of Medical Imaging

基　　金：湖北省卫健委科研立项项目(编号:WJ2019M030);湖北省武汉市卫健委医学科研项目(编号:WX18B11)。

摘　　要：目的 应用极速脉搏波技术评价糖尿病前期患者颈动脉弹性功能。方法 选取颈动脉结构正常的糖尿病前期和2型糖尿病患者各40例,分为糖尿病前期组和糖尿病组;选取40例健康体检者作为对照组。记录3组的临床资料、内中膜厚度(CIMT)及UFPWV技术测量数值(PWV-BS、PWV-ES)。对上述数据进行统计学分析。结果 三组间SBP、FPG、TG、TC和HDL-C差异有统计学意义(P <0.05)。糖尿病组的CIMT与对照组相比差异有统计学意义(P <0.05),而糖尿病前期组CIMT与对照组相比较差异无统计学意义。三组间PWV-ES差异有统计学意义(P <0.05),而PWV-BS与对照组相比较差异无统计学意义。PWV-BS、PWV-ES与年龄、SBP、FPG、TG、TC、CIMT均呈正相关(P <0.05),与HDL-C呈负相关(P <0.05)。PWV-BS的影响因素均包括年龄、SBP、FPG,PWV-ES的影响因素均包括年龄、SBP、FPG、TC。结论 UFPWV可以早期、准确、敏感地检测糖尿病前期患者颈动脉的弹性变化。PWV-ES较PWV-BS能更好定量反映颈动脉弹性变化,为糖尿病前期患者动脉硬化的早期评估提供一种新的手段。Objective To evaluate the change of carotid artery elasticity in prediabetes patients by UFPWV.Methods Carotid properties were evaluated in 120 consecutive subjects(40 volunteers for controls,40 patients with normal CIMT for prediabetes group,and 40 patients with normal CIMT for T2DM group).The clinical data,CIMT and UFPWV data of 3 groups were collected.Then statistical analysis of the above data was performed.Results SBP,FPG,TG and TC were significant higher in prediabetes group and T2DM group than those of in control group(P<0.05),while,the level of HDL-C was lower in prediabetes group and T2DM group than that of in control group(P<0.05).CIMT in T2DM group was higher than that of in control group(P<0.05),but there was no significant difference in CIMT between the prediabetes group and control group.Apart from PWV-BS in prediabetes group,PWV-ES was significant higher in prediabetes group and T2DM group than that of in control group(P<0.05).PWV-BS and PWV-ES were positively correlated with age,SBP,FPG,TG,TC and CIMT(all P<0.05),but negatively correlated with HDL-C(P<0.05).Age,SBP and FPG were risk factors for PWV-BS.Age,SBP,FPG and TC were risk factors for PWV-ES.Conclusion UFPWV can detect carotid artery elasticity changes in prediabetes patients early,accurately and sensitively.The PWV-ES seems to be a better biomarker candidate than PWV-BS to assess the early carotid stiffness.Carotid UFPWV measurement is a novel modality for the early diagnosis and quantitative assessment of arterial stiffness in prediabetes patients.

关 键 词：糖尿病前期 糖尿病 2型 颈动脉 弹性 超声检查 极速脉搏波速度 

分 类 号：R543.5[医药卫生—心血管疾病] R445.1[医药卫生—内科学]