牛蒡甘桔汤加减联合头孢硫脒治疗小儿急性扁桃体炎的临床疗效观察  

Clinical Effect of Modified Niubang Ganju Decoction Combined with Cefathiamidine in Treatment of Pediatric Acute Tonsillitis

作　　者：李晓英 梅涛 王宇 王淮燕 LI Xiaoying;MEI Tao;WANG Yu;WANG Huaiyan(Changzhou Maternal and Child Health Hospital,Changzhou 213000,China)

机构地区：[1]常州市妇幼保健院,江苏常州213000

出　　处：《中医药学报》2022年第11期82-86,共5页Acta Chinese Medicine and Pharmacology

基　　金：常州市卫健委科技项目(QN202049)。

摘　　要：目的:观察牛蒡甘桔汤加减联合头孢硫脒治疗小儿急性扁桃体炎的临床疗效。方法:选取2019年6月—2021年5月常州市妇幼保健院收治的132例急性扁桃体炎患儿,采用随机数字表法分为对照组(头孢硫脒治疗,66例)和观察组(牛蒡甘桔汤加减+头孢硫脒治疗,66例)。对比两组患儿中医证候评分、有关症状改善时间、临床疗效、免疫功能指标及不良反应发生情况。结果:治疗后两组患儿主症、次症评分及总分均明显降低(P<0.05),且观察组临床症状评分均低于对照组(P<0.05);观察组体温恢复正常时间、脓痰消退时间及咽部充血消失时间均短于对照组(P<0.05);观察组总有效率为96.97%(64/66)高于对照组的84.85%(56/66),两组比较,差异有统计学意义(P<0.05);治疗后两组患儿血清一氧化氮(NO)、免疫球蛋白G(IgG)及免疫球蛋白M(IgM)均升高(P<0.05),且观察组均高于对照组(P<0.05);两组患儿不良反应总发生率对比,差异无统计学意义(P>0.05)。结论:牛蒡甘桔汤加减联合头孢硫脒治疗小儿急性扁桃体炎可缓解患儿的临床症状,缩短症状改善时间,提高临床疗效及免疫功能,且安全可靠。Objective:To observe the clinical effect of modified Niubang Ganju Decoction combined with Cefathiamidine in treatment of pediatric acute tonsillitis.Methods:132 children with acute tonsillitis were randomly divided into the control group(n=66)and the observation group(n=66).The control group was treated with Cefathiamidine;on which basis,the observation group was also treated with modified Niubang Ganju Decoction.The scores of TCM symptoms,the time of symptoms improvements,clinical efficacy,immune function indexes and adverse reactions were compared between the two groups.Results:The scores of primary symptoms,secondary symptoms and total scores were statistically decreased after treatment compared with those before treatment in the two groups(P<0.05),and the clinical symptom scores of the observation group were lower than those of the control group after treatment(P<0.05).The time of body temperature returned to normal,the time of purulent sputum subsidence and the time of pharyngeal hyperemia disappearance were shorter in the observation group than those in the control group(P<0.05).The total effective rate of the observation group was 96.97%(64/66),which was statistically higher than 84.85%(56/66)of the control group(P<0.05).The serum nitric oxide(NO),immunoglobulin G(IgG)and immunoglobulin M(IgM)were increased after treatment in the two groups(P<0.05),which were significantly higher in the observation group than those in the control group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The modified Niubang Ganju Decoction combined with Cefathiamidine can relieve the clinical symptoms of children with acute tonsillitis,shorten the time of symptoms improvements,improve clinical efficacy and immune function,which is safe and reliable.

关 键 词：小儿急性扁桃体炎 牛蒡甘桔汤 头孢硫脒 

分 类 号：R272[医药卫生—中医儿科学]