甲状腺癌病理微血管密度与颈部淋巴结转移相关性研究  

Correlation between pathological microvessel density and cervical lymph node metastasis in thyroid cancer

作　　者：石维超 张少波 SHI Weichao;ZHANG Shaobo(The Second Affiliated Hospital of Xi’an Medical College,Xi’an 710038,China)

机构地区：[1]西安医学院第二附属医院,陕西西安710038 [2]西安交通大学附属红会医院外二科,陕西西安710054

出　　处：《陕西医学杂志》2022年第11期1449-1452,共4页Shaanxi Medical Journal

基　　金：陕西省重点研发计划项目(2019SF-049)。

摘　　要：目的:探讨甲状腺癌病理微血管密度(MVD)与颈部淋巴结转移的相关性。方法:210例甲状腺癌患者作为研究对象,所有患者均给予病理MVD计数,采用超声确定范围,病理判读的方式判定颈部淋巴结转移情况并进行相关性分析。结果:在210例患者中,颈部淋巴结转移78例,发生率37.1%,其中Ⅰ区22例,Ⅱ区8例,Ⅲ区19例,Ⅳ区21例,Ⅴ区6例,Ⅵ区2例。转移组的性别、年龄、体重指数、发病位置、病理类型等与非转移组对比无统计学差异(均P>0.05),两组临床分期、组织学分化程度等对比有统计学差异(P<0.05)。转移组的病理平均MVD计数显著多于非转移组(P<0.05)。Pearson分析显示甲状腺癌的病理平均MVD计数与颈部淋巴结转移存在正相关性(r=0.762,P=0.000);Logistic回归分析显示临床分期、组织学分化程度、病理平均MVD计数均为影响颈部淋巴结转移的主要因素(均P<0.05)。结论:甲状腺癌患者多伴有颈部淋巴结转移,病理平均MVD增加,可导致颈部淋巴结的转移,两者存在相关性,临床分期、组织学分化程度、病理平均MVD计数都为影响颈部淋巴结转移的主要因素。Objective:To explore the correlation between pathological microvessel density(MVD)and cervical lymph node metastasis in thyroid cancer.Methods:A total of 210 thyroid cancer patients were collected as research objects.All patients were given pathological MVD counts,and ultrasound were used to determine cervical lymph node metastasis,and correlation analysis was carried out.Results:Of the 210 patients,78 had cervical lymph node metastasis,with a 37.1%incidence rate,including 22 in zoneⅠ,8 in zoneⅡ,19 in zoneⅢ,21 in zoneⅣ,6 in zoneⅤand 2 in zoneⅥ.There were no significant difference in gender,age,body mass index,disease location,pathological type,etc.between the metastatic group and the non-metastatic group(all P>0.05).There were significant differences in clinical stage and degree of histological differentiation between the two groups(all P<0.05).The mean MVD count in the metastatic group were significantly higher than that in the non-metastatic group(P<0.05).Pearson analysis showed that the pathological mean MVD count was positively correlated with cervical lymph node metastasis in thyroid cancer(r=0.762,P=0.000).Logistic regression analysis showed that clinical stage,degree of histological differentiation and pathological mean MVD count were the main risk effects for the cervical lymph node metastasis in thyroid cancer(all P<0.05).Conclusion:Patients with thyroid cancer are often accompanied by cervical lymph node metastasis.Pathological mean MVD increases can lead to cervical lymph node metastasis.There is a correlation between the two.Clinical stage,degree of histological differentiation and pathological average MVD count are the main factors affecting cervical lymph node metastasis.

关 键 词：甲状腺癌 颈部淋巴结转移 微血管密度 临床分期 组织学分化程度 相关性 

分 类 号：R736.1[医药卫生—肿瘤]