SOCS的免疫调节机制及其在慢性肝病中的作用  

Immunoregulatory mechanism of SOCS and its role in chronic liver disease

作　　者：赵家洁 游晶(指导)[1] 李静 赵寅洲 ZHAO Jiajie;YOU Jing;LI Jing;ZHAO Yinzhou(Department of Infectious Diseases and Hepatology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院感染性疾病和肝病科,昆明650032 [2]昆明医科大学公共卫生学院,昆明650500

出　　处：《中国免疫学杂志》2022年第17期2140-2146,共7页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81760111,81760617)资助。

摘　　要：细胞因子转导抑制因子(SOCS)是细胞外信号引起的信号转导过程中关键的负调控因子,SOCS家族通过一系列机制负调控Janus激酶/信号转导子和转录激活子(JAK/STAT)信号通路,从而调节靶基因的表达而发挥生物学作用,在免疫相关疾病、肿瘤疾病中扮演重要角色。目前越来越多的研究证明,在各种慢性肝病(CLD),包括慢性病毒性肝炎、非酒精性脂肪肝、肝纤维化、肝癌等疾病中存在SOCS蛋白表达异常,研究SOCS在慢性肝病中的作用机制,可能为相关肝病的治疗提供新的策略。本文简要介绍了SOCS的免疫调节机制,重点阐述了其在各种慢性肝病中的作用。Suppressor of cytokine signaling(SOCS)is a key negative regulator in process of cell signal transduction induced by extracellular signals. SOCS family negatively regulates Janus kinase/signal transducers andactivators of transcription(JAK/STAT)signaling pathway through a series of mechanisms,thereby regulating expressions of target genes to play a biological role in immune. It plays an important role in immune-related diseases and tumor diseases. At present,more and more studies also prove that there are abnormal expression of SOCS protein in various chronic liver diseases(CLD),including chronic viral hepatitis,non-alcoholic fatty liver,hepatic fibrosis,liver cancer and other diseases. To study the mechanism of SOCS in chronic liver disease,may provide new treatment strategies for liver disease treatment. This article briefly describes the mechanism of action of SOCS,focusing on its role in various chronic liver diseases.

关 键 词：细胞因子转导抑制因子 JANUS激酶 信号转导子和转录激活子 信号通路 慢性肝病 

分 类 号：R512.6[医药卫生—内科学]