乙肝疫苗接种无应答者免疫因素的研究进展  

Research progress of immune factors in unresponsive hepatitis B vaccine recipients

作　　者：赵梅娥 张慧[2] 甄宏斌 黄焕源 王春霞(指导) 谢小冬(指导)[3] ZHAO Mei'e;ZHANG Hui;ZHEN Hongbin;HUANG Huanyuan;WANG Chunxia;XIE Xiaodong(The First People's Hospital of Lanzhou City,Lanzhou 730000,China)

机构地区：[1]兰州市第一人民医院,兰州730000 [2]甘肃省疾病预防控制中心,兰州730000 [3]兰州大学基础医学院遗传所,兰州730000

出　　处：《中国免疫学杂志》2022年第18期2292-2296,共5页Chinese Journal of Immunology

基　　金：甘肃省科技创新服务平台建设项目(18JR2TA024);甘肃省青年科技基金计划(20JR5RA141)资助。

摘　　要：接种乙型肝炎疫苗是预防乙型肝炎病毒感染的有效策略,但仍有5%~10%的接种者无应答,机制尚未明确。乙肝疫苗无应答受多种因素影响,主要有疫苗因素、机体自身特征及环境特征、免疫相关遗传因素及分子特征等方面,其中免疫相关遗传因素及分子特征对乙肝疫苗免疫应答起关键作用。本文主要对乙型肝炎病毒疫苗接种无应答者的免疫相关遗传因素及细胞分子特征的研究进展进行阐述,旨在为乙型肝炎病毒疫苗免疫无应答的遗传机制研究提供理论依据。Inoculation of hepatitis B vaccine is an effective strategy to prevent hepatitis B virus infection. However,there is still 5%~10% of patients vaccinat presented status of no response,which is influenced by many factors,whose main factors including vaccine factors,organism’s own characteristics and environmental characteristics,immune-related genetic factors and molecular characteristics,etc.,in which immune-related genetic factors and molecular characteristics play a key role in immune responses on hepatitis B vaccine. This paper mainly describes research progress of immune-related genetic factors and molecular characteristics of nonresponders to hepatitis B virus vaccination,to provide a theoretical basis for study of genetic mechanism of immune non-response to hepatitis B virus vaccine.

关 键 词：乙型肝炎病毒 乙型肝炎疫苗 免疫无应答 

分 类 号：R392.2[医药卫生—免疫学]