调节性B细胞在妊娠合并系统性红斑狼疮中的研究进展  

Research progress of association between regulatory B cells and systemic lupus erythematosus in pregnancy

作　　者：林思涵 王酉[1] 狄文(指导)[1] LIN Sihan;WANG You;DI Wen(Department of Obstetrics and Gynecology,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Key Laboratory of Gynecologic Oncology,State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院妇产科,上海市妇科肿瘤重点实验室,癌基因及相关基因国家重点实验室,上海200127

出　　处：《中国免疫学杂志》2022年第18期2297-2302,共6页Chinese Journal of Immunology

基　　金：上海市科学技术委员会科研计划项目(18441904800);上海市卫生和计划生育委员会项目(2017ZZ02016)资助。

摘　　要：系统性红斑狼疮(SLE)是累及多器官组织的慢性自身免疫性疾病,多见于育龄期女性。因SLE特征性的免疫紊乱可能为母体和胎儿带来风险,所以SLE孕妇被视为高危孕产妇。妊娠过程涉及精密的免疫调节,保护“同种半异体移植物”胚胎免受母体免疫细胞的攻击,是良好妊娠结局的保障。调节性B细胞(Bregs)在妊娠及包括SLE在内的多种自身免疫性疾病中具有重要作用,其通过分泌多种细胞因子以及与其他免疫细胞相互作用,参与负向免疫调节,对妊娠结局和SLE发生发展有不可忽视的影响。本文主要就当前Bregs在妊娠合并SLE中的研究进展进行归纳和阐述。Systemic lupus erythematosus(SLE)is a chronic multi-organ autoimmune disorder,with predominant female patients of child-bearing age. The typified immune disorders in SLE may pose a threat to both mother and the fetus,and thus pregnant SLE patients are associated with higher risks than healthy pregnant females. The key to ensuring a safe pregnancy is the delicate modification of maternal immune system,which protects semi-allogenic fetus from immune attacks from mother. Regulatory B cells(Bregs)play a critical role in pregnancy and several autoimmune diseases including SLE. Bregs are engaged in negative modulation of immunity via the secretion of various cytokines and the interaction with other immune cells,having an indispensable influence on pregnancy outcomes and the development of SLE. In this paper,we aim to summarize the research progress of Bregs in pregnancy complicated with SLE.

关 键 词：调节性B细胞 系统性红斑狼疮 母胎免疫耐受 白细胞介素-10 

分 类 号：R392[医药卫生—免疫学]