不同型别银屑病炎症相关临床特征及实验室指标的比较  

Comparison of inflammation-related clinical characteristics and laboratory parameters among different types of psoriasis

作　　者：唐增奇[1] 邱枭男 段妤 TANG Zengqi;QIU Xiaonan;DUAN Yu(Department of Dermatology,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen university,510120,China;Department of Ultrasonic,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen university,510120,China)

机构地区：[1]中山大学孙逸仙纪念医院皮肤科,广东广州510120 [2]中山大学孙逸仙纪念医院超声医学科,广东广州510120

出　　处：《皮肤性病诊疗学杂志》2022年第5期434-438,共5页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：国家自然科学基金(81872524)。

摘　　要：目的探讨寻常型银屑病(PV)、红皮病型银屑病(EP)和泛发性脓疱型银屑病(GPP)患者的4种常见炎症相关临床特征及实验室指标,包括发热、白细胞计数、C反应蛋白(CRP)和红细胞沉降率(ESR)等方面的差异。方法单中心回顾性研究近10年我科163例银屑病住院患者。比较PV(58例)、EP(48例)、GPP(57例)三组间体温、血细胞计数等资料的差异。结果GPP组年龄低于30岁患者比例显著高于EP组和PV组。EP组和GPP组患者入院首日发热比例分别为66.67%和77.19%,显著高于PV组(10.34%)。EP组和GPP组患者出现白细胞升高的比例分别为43.75%、73.68%,出现中性粒细胞升高(>7.5×10^(9)/L)的比例分别为33.33%、66.67%,均显著高于PV组(分别为12.07%、3.45%),而GPP组相应比例显著高于EP组,差异均有统计学意义(均P<0.05)。EP组和GPP组患者出现单核细胞升高的比例分别为20.83%、36.84%,存在CRP升高的比例分别为81.52%、87.72%,存在ESR升高的比例分别为83.33%、84.21%,均显著高于PV组(分别17.24%、15.52%),差异均有统计学意义(均P<0.05)。结论与PV患者比较,EP和GPP患者临床更容易出现发热症状,以及白细胞、中性粒细胞、单核细胞、CRP和ESR升高等炎症标志异常。GPP患者白细胞和中性粒细胞升高比例高于EP患者。不同型别的银屑病在以上常见炎症相关临床特征及实验室指标方面存在明显差异,提示其发病机制可能不同,临床治疗方案理应有别。Objective This study aimed to investigate the differences in inflammation-related clinical features and laboratory parameters,including fever,white blood cell count,C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR),among patients with psoriasis vulgaris(PV),erythrodermic psoriasis(EP),and generalized pustular psoriasis(GPP).Methods This single-center retrospective study included 163 psoriatic inpatients from our department in the past 10 years.Pearson's chi-square test was used to analyze demographic data,body temperature and blood cell counts.One-way ANOVA and Dunns POST test were used to analyze gaussian distribution data,while Kruskal-Wallis test was used for analysis of non-Gaussian distribution data.Results In term of age distribution,the proportion of patients under 30 years old in GPP group was significantly higher than that in EP and PV groups.The rates of fever on the first day of admission were significantly higher in EP(66.67%)and GPP(77.19%)groups than in PV group(10.34%).Likewise,higher proportion of patients in EP and GPP displayed high leukocyte count(>10×10^(9)/L)than that in PV group(43.75% and 73.68%vs 12.07%and 3.45%).Moreover,more patients in GPP group had high leukocyte count than that in the EP group.Similarly,proportion of patients with high neutrophil count(>7.5×10^(9)/L)was also significantly higher in EP(33.33%)and GPP(66.67%)groups than in PV group.Again,proportion of patients with high neutrophil count was higher in the GPP group than in EP group.Furthermore,high monocyte count(>1×10^(9)/L)was found in 20.83% of patients in EP group and 36.84% in GPP group,which both were significantly higher than that in the PV group.Additionally,81.25% of patients in EP group and 87.72%in GPP group displayed increased CRP,which both were higher than that in PV group(17.24%).Finally,increased ESR was found in 83.33% of patients in EP group and 84.21%in GPP group(both P<0.05 vs 15.52%in PV group).Conclusions Compared with PV,patients with EP and GPP are more likely to develop inflammat

关 键 词：银屑病 实验室指标 寻常型银屑病 泛发性脓疱型银屑病 红皮病型银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]