氨溴索联合布地奈德治疗婴幼儿支气管肺炎的效果  

Efficacy of ambroxol combined with budesonide in the treatment of infantile bronchopneumonia

作　　者：周培培 张舒婷 ZHOU Peipei;ZHANG Shuting(Department of Pediatrics,Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University,Xuzhou No.1 People’s Hospital,Jiangsu,Xuzhou 221100,China)

机构地区：[1]徐州医科大学附属徐州市立医院江苏省徐州市第一人民医院儿科,江苏徐州221100

出　　处：《中国医药科学》2022年第19期147-151,共5页China Medicine And Pharmacy

摘　　要：目的探讨氨溴索联合布地奈德雾化治疗对婴幼儿支气管肺炎的效果。方法选取2020年1月至2021年6月徐州市第一人民医院收治的婴幼儿支气管肺炎96例,按照随机数表法分为观察组和对照组,每组各48例。对照组采用布地奈德雾化吸入,观察组在此基础上联合氨溴索雾化吸入。比较两组发热、咳嗽及湿啰音等症状体征的持续时间及住院时间,治疗前后C反应蛋白(CRP)、白细胞(WBC)计数、核因子-κB(NF-κB)、细胞因子、氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、总有效率及不良反应等指标。结果治疗后,观察组患儿的咳嗽、肺湿啰音、发热持续时间及住院时间均短于对照组,差异有统计学意义(P<0.05);观察组CRP、WBC、NF-κB、IL-4和PaCO_(2)均低于对照组,差异有统计学意义(P<0.05);观察组IFN-γ和PaO_(2)明显高于对照组,差异有统计学意义(P<0.05);观察组总有效率为93.75%,高于对照组的77.08%,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论布地奈德联合氨溴索雾化治疗婴幼儿支气管肺炎的效果确切,能够改善患儿肺功能,抑制其炎性反应,临床上值得推广应用。Objective To investigate the effect of ambroxol combined with budesonide in the treatment of bronchopneumonia in infants.Methods A total of 96 infants with bronchopneumonia treated in Xuzhou No.1 People’s Hospital from January 2020 to June 2021 were selected and randomly divided into two groups,with 48 cases in each group.The control group was treated with budesonide atomization inhalation,and the observation group was combined with ambroxol atomization inhalation.The duration of symptoms and signs such as fever,cough and wet rale and the length of hospital stay were compared between the two groups.Indexes of CRP,WBC,NF-κB、cytokines,PaO_(2),PaCO_(2),total efficiency,and adverse reactions were compared.Results After treatment,the duration of cough,lung rales,fever and hospitalization of the observation group were shorter than those of the control group,with statistically significant differences(P<0.05).The CRP,WBC,NF-κB,IL-4 and PaCO_(2)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).IFN-γand PaO_(2)in the observation group were significantly higher than those in the control group,with statistically significant differences(P<0.05).The total effective rate of the observation group was 93.75%,higher than 77.08%of the control group,with statistically significant differences(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Budesonide combined with ambroxol atomization is effective in the treatment of infantile bronchopneumonia.It can improve children’s lung function and inhibit their inflammatory response,which is worthy of application in c linic.

关 键 词：氨溴索 布地奈德 婴幼儿 支气管肺炎 肺功能 

分 类 号：R722.135[医药卫生—儿科]