中药单体改善卵巢早衰的作用机制研究进展  

Advances of the mechanism study on Chinese herb monomers in improving premature ovarian failure

作　　者：严如根 王雨琦 何静 陈银 蔡平平 李长忠 YAN Rugen;WANG Yuqi;HE Jing;CHEN Yin;CAI Pingping;LI Changzhong(School of Traditional Chinese Medicine&School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Dept.of Obstetrics and Gynecology,Xuyi County Hospital of Chinese Medicine,Jiangsu Xuyi 211700,China;Dept.of TCM,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250012,China)

机构地区：[1]南京中医药大学中医学院·中西医结合学院,南京210023 [2]山东中医药大学第一临床医学院,济南250355 [3]盱眙县中医院妇产科,江苏盱眙211700 [4]山东第一医科大学附属省立医院中医科,济南250012

出　　处：《中国药房》2022年第21期2685-2688,共4页China Pharmacy

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目(No.国中医药人教函〔2018〕134号);国家中医药管理局第五批全国中医临床优秀人才研修项目(No.国中医药人教函〔2022〕1号);山东省重点研发计划项目(No.2019GSF108197)。

摘　　要：卵巢早衰是妇科内分泌常见病,可引发卵巢内卵泡发育停滞或提前衰竭,从而导致卵巢功能丧失,严重影响女性的身心健康。我国传统中药治疗卵巢早衰的毒副作用较少、效果显著。中药单体是中药发挥药效的活性成分,且化学结构确定。笔者从中药单体角度出发,综述其改善卵巢早衰的作用机制,结果发现,淫羊藿苷、槲皮素、白藜芦醇、人参皂苷Rg_(1)可通过激活卵巢组织磷脂酰肌醇3-激酶/蛋白激酶B信号通路、抑制氧化应激和颗粒细胞凋亡、促进卵巢细胞自噬、调节性激素水平来改善卵巢早衰模型动物的卵巢功能;葛根素、白藜芦醇可通过干预卵巢组织Wnt/β-连环蛋白信号通路、减轻氧化应激反应、抑制卵泡闭锁来改善卵巢早衰模型动物的卵巢功能等。虽然目前中药单体在改善卵巢早衰方面具有一定效果,但大多数停留在实验阶段,尚不能客观评价其改善卵巢早衰的临床疗效。后续应加强中药单体新剂型的开发,以期为治疗卵巢早衰的新药开发奠定基础。Premature ovarian failure(POF)is a common gynecological endocrine disease,which can cause follicular development stagnation or premature failure in the ovary,leading to ovarian function loss,and seriously affecting women’s physical and mental health.Traditional Chinese medicine shows less toxicity and side effects but significant effect in the treatment of POF.Chinese herb monomers are the active ingredients of traditional Chinese medicine that exert their effects,and their chemical structure are determined.From the perspective of Chinese herb monomers,the author reviewed the mechanism of their effect on improving POF.The results showed that icariin,quercetin,resveratrol and ginsenoside Rg_(1) could improve the ovarian function of POF model animals by activating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway,inhibiting oxidative stress and apoptosis of granulosa cells,promoting ovarian autophagy,and regulating the level of sex hormones;puerarin and resveratrol can improve the ovarian function of POF model by interfering with Wnt/β-catenin signaling pathway,reducing oxidative stress response,and inhibiting follicular atresia.Although the Chinese herb monomers have certain effect in improving POF,most of them remain in the experimental stage,and the clinical efficacy in improving POF cannot be objectively evaluated.In the future,the development of new dosage forms of Chinese herb monomers should be strengthened to lay a foundation for the development of new drugs for treating POF.

关 键 词：卵巢早衰 中药单体 作用机制 

分 类 号：R965[医药卫生—药理学]