妊娠期高血压疾病患者孕晚期血清PLGF、VEGF水平与胎儿生长受限的关系  

Relationships between serum PLGF and VEGF levels and fetal growth restriction in patients with hypertensive disorder complicating pregnancy in the third trimester

作　　者：朱念念 赵敏[1] 夏闪 ZHU Niannian;ZHAO Min;XIA Shan(Department of Obstetrics and Gynecology,The Affiliated Chuzhou Hospital of Anhui Medical University/The First People's Hospital of Chuzhou,Chuzhou 239000,China)

机构地区：[1]安徽医科大学附属滁州医院(滁州市第一人民医院)妇产科,安徽滁州239000

出　　处：《山东医药》2022年第31期31-34,共4页Shandong Medical Journal

基　　金：安徽省卫生健康委科研项目(AHWJ2019B041)。

摘　　要：目的 探讨妊娠期高血压疾病(HDP)患者孕晚期血清胎盘生长因子(PLGF)、血管内皮生长因子(VEGF)水平与胎儿生长受限(FGR)的关系。方法 选取孕晚期HDP患者187例,根据是否发生FGR分为FGR组52例、非FGR组135例。采集研究对象入组时静脉血,分离血清,用酶联免疫吸附法检测血清PLGF、VEGF。Pearson相关分析血清PLGF与VEGF水平的相关性;多因素Logistic回归分析孕晚期HDP患者发生FGR的影响因素;受试者工作特征(ROC)曲线分析血清PLGF、VEGF对孕晚期HDP患者发生FGR的预测价值。结果 FGR组收缩压、舒张压高于非FGR组,血清PLGF、VEGF水平低于非FGR组(P均<0.05);两组年龄、孕周比较差异无统计学意义(P均>0.05)。Pearson相关分析显示,FGR组血清PLGF水平与VEGF水平呈正相关(r=0.691,P<0.05)。多因素Logistic回归分析显示,调整血压后,血清PLGF、VEGF水平升高为HDP患者发生FGR的独立保护因素(P均<0.05)。ROC曲线分析显示,血清PLGF水平预测孕晚期HDP患者发生FGR的曲线下面积、最佳截断值、敏感度、特异度分别为0.762(95%CI:0.695~0.821)、231.40 pg/mL、71.15%、73.33%;血清VEGF水平预测孕晚期HDP患者发生FGR的曲线下面积、最佳截断值、敏感度、特异度分别为0.815(95%CI:0.752~0.868)、423.90 pg/mL、94.23%、57.78%;血清PLGF、VEGF水平联合预测孕晚期HDP患者发生FGR的曲线下面积、敏感度、特异度分别为0.856(95%CI:0.798~0.903)、92.31%、62.22%。血清PLGF、VEGF水平联合预测孕晚期HDP患者发生FGR的曲线下面积大于血清PLGF、VEGF水平单独预测(P均<0.05)。结论 孕晚期HDP患者血清PLGF、VEGF水平降低,二者水平升高为FGR发生的独立保护因素,可作为孕晚期HDP患者发生FGR的预测指标。Objective To investigate the relationships between serum placental growth factor(PLGF) and vascular endothelial growth factor(VEGF) levels and fetal growth restriction(FGR) in patients with hypertensive disorder complicating pregnancy(HDP) in the third trimester.Methods A total of 187 patients with HDP in the third trimester were selected and were divided into the FGR group(52 cases) and non-FGR group(135 cases) according to whether FGR occurred.The venous blood was collected from the subjects when they were enrolled;the serum was separated,and the serum PLGF and VEGF were detected by enzyme-linked immunosorbent assay.Pearson correlation was used to analyze the correlation between serum PLGF and VEGF levels.Multivariate Logistic regression analysis was used to analyze the influencing factors of FGR in HDP patients in the third trimester;the receiver operating characteristic(ROC) curve was used to analyze the predictive value of serum PLGF and VEGF for FGR in HDP patients in the third trimester.Results The systolic blood pressure and diastolic blood pressure in the FGR group were higher than those in the non-FGR group,and the serum levels of PLGF and VEGF were lower than those in the non-FGR group(all P0.05).Pearson correlation analysis showed that serum PLGF level was positively correlated with VEGF level in FGR group(r=0.691,P<0.05).Multivariate Logistic regression analysis showed that,after adjusting blood pressure,increased serum PLGF and VEGF levels were independent protective factors for FGR in HDP patients(all P<0.05).The ROC curve showed that the area under the curve,optimal cut-off value,sensitivity,and specificity of serum PLGF in predicting FGR in HDP patients in the third trimester were0.762(95% CI:0.695-0.821),231.40 pg/mL,71.15%,and 73.33%,respectively;the area under the curve,optimal cut-off value,sensitivity,and specificity of serum VEGF in predicting FGR in HDP patients in the third trimester were0.815(95% CI:0.752-0.868),423.90 pg/mL,94.23%,and 57.78%,respectively;the area under the curve,sensiti

关 键 词：妊娠期高血压疾病 胎儿生长受限 胎盘生长因子 血管内皮生长因子 

分 类 号：R714.24[医药卫生—妇产科学]