树突状细胞亚群及其在疾病中的作用研究进展  

Advances in dendritic cell subsets and their role in diseases

作　　者：冯萌 林玮(指导) FENG Meng;LIN Wei(School of Basic Medicine,Shandong First Medical University,Jinan 250062,China)

机构地区：[1]山东第一医科大学基础医学院,济南250062

出　　处：《中国免疫学杂志》2022年第16期2020-2025,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81500710);山东省重点研发计划(2019GSF108189)资助。

摘　　要：树突状细胞(DCs)来源于骨髓造血干细胞(HSCs)的一类高度异质性细胞,作为体内极其重要的专职性抗原提呈细胞和免疫协调器,具有显著的细胞表型和功能可塑性。近年来,通过高通量分析等技术发现了一些新的DCs亚群。免疫微环境赋予了DCs不同的亚群特征,不同的DCs亚群在不同的组织器官或疾病中发挥免疫调节作用。并为肿瘤移植排斥、自身免疫性疾病等疾病的治疗提供新思路。本文综述了DCs亚群的研究进展以及其在免疫相关性疾病中的作用。Dendritic cells(DCs)are a kind of highly heterogeneous cell derived from bone marrow Hematopoietic stem cells(HSCs). As extremely important professionalantigen-presenting cell and immune coordinator in the body,they have significant cells phenotype and functional plasticity. In recent years,some new DCs subsets have been discovered by using techniques such as highthroughput analysis,and so on. The immune microenvironment endows DCs with different subpopulation characteristics,and these DCs subpopulations play different immunomodulatory roles in different tissues or diseases. And provide new ideas for the treatment of tumors,transplant rejection,autoimmune diseases and other diseases. This article reviews the recent research progress of DCs subsets and their role in immune-related diseases.

关 键 词：树突状细胞 亚群 免疫调节 分化发育 肿瘤 自身免疫疾病 

分 类 号：R392[医药卫生—免疫学]