KANNO血型系统(KANNO,037)的研究进展  

A review:KANNO(KANNO,037) blood group system

作　　者：钟靖 龚晨辉[2] 史华山 李凌波 ZHONG Jing;GONG Chenhui;SHI Huashan;LI Lingbo(Department of Blood Transfusion,the Shaoyang Central Hospital,Shaoyang 422000,China)

机构地区：[1]邵阳市中心医院输血科,邵阳422000 [2]南昌大学第二附属医院,南昌330006 [3]磁县人民医院,磁县056500 [4]长春博迅生物技术有限责任公司,长春130102

出　　处：《中国免疫学杂志》2022年第16期2037-2044,共8页Chinese Journal of Immunology

基　　金：吉林省科技厅科技发展计划资助项目(20160204016SF)。

摘　　要：KANNO血型系统是国际输血协会(ISBT)2019年确认的独立的血型系统,命名KANNO,数字命名037,由1个抗原组成。2019年确认了KANNO抗原的基因是位于第20号染色体的朊蛋白(PrP)PRNP基因,编码产物是红细胞KANNO糖蛋白,所确定的单核苷酸多态性(SNPs)位于PRNP基因的219位密码子,由氨基酸发生谷氨酸(Glu)到赖氨酸(Lys)的基因突变(E219K)定义了KANNO阴性表型。红细胞同种抗体抗-KANNO于1991年在一名有孕史的日本女性体内发现,目前尚无抗-KANNO抗体导致溶血性输血反应(HTRs)或者新生儿溶血性疾病(HDFN)的报道。本文就KANNO血型系统研究进展作一综述。The KANNO blood group system is an independent blood group system identified by International Society of Blood Transfusion(ISBT)in 2019. It is named KANNO and 037 digitally. It consists of 1 antigens. In 2019,it was confirmed that the KANNO antigen gene,prion protein gene(PRNP),is located on chromosome 20 and encodes RBC KANNO glycoprotein. A single nucleotide polymorphism(SNP)of PRNP at codon 219 leads to the occurrence of a glutamate(Glu)to lysine(Lys)(E219K)substitution,which is defined as KANNO-negative phenotype. The red blood cell(RBC)alloantibody anti-KANNO was discovered in 1991 in a Japanese woman. However,thus far,there have been no reports of anti-KANNO-induced hemolytic transfusion reactions(HTRs)or hemolytic disease of the fetus and newborn(HDFN). In this review,the study progress in KANNO blood group system is summarized.

关 键 词：KANNO 血型系统 PRNP 朊蛋白 

分 类 号：R457.11[医药卫生—治疗学]