聚焦超声治疗外阴上皮内非瘤样病变的系统评价  

Systematic evaluation on focused ultrasound in treating non-neoplastic epithelial disorders of vulva

作　　者：郑越 常淑芳[1] ZHENG Yue;CHANG Shufang(Department of Obstetrics and Gynecology,Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院妇产科,400010

出　　处：《重庆医学》2022年第21期3721-3725,3733,共6页Chongqing medicine

基　　金：国家自然科学基金项目(81972439)。

摘　　要：目的系统评价聚焦超声治疗外阴上皮内非瘤样病变的疗效和安全性,为临床聚焦超声治疗提供依据。方法计算机检索PubMed、CNKI、万方和维普数据库,检索时限为2012年9月至2021年12月。由2名研究者根据纳入及排除标准独立筛选文献、提取资料和评价研究质量,数据分析采用RevMan5.4软件。结果纳入10篇中文文献,共1210例外阴上皮内非瘤样病变患者,随访时间为3~12个月,其中7篇文献对照组为药物治疗,3篇文献对照组为微波治疗,试验组均为聚焦超声治疗。有效性分析显示:和传统治疗方式(药物和微波)比较,聚焦超声治疗该疾病的有效率更高(RR=1.20);分别和药物、微波治疗比较,聚焦超声治疗有效率更高(RR=1.27、1.12)。复发率分析显示:聚焦超声治疗复发率低于药物(RR=0.08)。安全性分析显示:聚焦超声治疗相关不良反应发生率低于药物(RR=0.15)。结论聚焦超声治疗外阴上皮内非瘤样病变值得临床进一步推广使用和研究。Objective To systematically evaluate the efficacy and safety of focused ultrasound in treating non-neoplastic intraepithelial lesions of vulva to provide a basis for clinical treatment of focused ultrasound.Methods The databases of PubMed,CNKI,WANFANG and VIP were retrieved by computer.The retrieval period was from September 2012 to December 2021.Two reviewers independently screened the literatures,extracted the data and evaluated the study quality.Then the data analysis adopted by using RevMan5.4 software.Results A total of 10 Chinese articles were included involving 1210 cases of non-neoplastic intraepithelial lesions of the vulva,the follow-up period was 3-12 months,in which the control group in 7 articles used the medication treatment and the control group in the other 3 articles used the microwave treatment,the experimental group in every article was treated by the focused ultrasound.The effectiveness analysis showed that compared with the traditional treatment mode medication and microwave treatments,the effective rate of focused ultrasound for treating this disease had higher effective rates(RR=1.20).Compared with the medication treatment and microwave treatment,the focused ultrasound treatment had higher effective rates(RR=1.27,1.12).The recurrence rate analysis showed that the recurrence rate of the focused ultrasound treatment was lower that that of the medication treatment(RR=0.08).The safety analysis showed that the occurrence rate of focused ultrasound related adverse reactions was lower than that of the medication treatment(RR=0.15).Conclusion Focused ultrasound in treating non-neoplastic intraepithelial lesions of vulva is worthy of further clinical promotion and research.

关 键 词：外阴上皮内非瘤样病变 聚焦超声 药物 微波 META分析 

分 类 号：R711.72[医药卫生—妇产科学]