HPLC法测定8种不同基原鲜竹沥中苯酚、对甲基苯酚和对乙基苯酚的含量  

Comparison of Phenol、Para-methyl Phenol and Para-ethyl Phenol Content in Xianzhuli of 8 Originals by HPLC

作　　者：肖小武 周志强 洪挺 付辉政 罗跃华 王伟[2] XIAO Xiao-wu;ZHOU Zhi-qiang;HONG Ting;FU Hui-zheng;LUO Yue-hua;WANG Wei(NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine,Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality,Jiangxi Institute For Drug Control,Jiangxi Nanchang 330029,China;Department of Oral and Maxillofacial Surgery,Affliated Hospital of Jiangxi University of Traditional Chinese Medicine,Jiangxi Nanchang 330006,China)

机构地区：[1]江西省药品检验检测研究院,江西省药品与医疗器械质量工程技术研究中心,国家药品监督管理局中成药质量评价重点实验室,江西南昌330029 [2]江西中医药大学附属医院口腔创伤整形科,江西南昌330006

出　　处：《中国药物评价》2022年第5期386-390,共5页Chinese Journal of Drug Evaluation

基　　金：国家药典委标准提高项目(2019Z085);江西省重点研发项目,江西特色抗疫品种复方鲜竹沥液的质量关键技术研究与应用(20203BBG73062);江西省药品监督管理局科研项目,江西省特色优势品种复方鲜竹沥液的质量标准提升研究(2020JS04)。

摘　　要：目的:比较8种不同基原鲜竹沥中苯酚、对甲基苯酚和对乙基苯酚的含量,为鲜竹沥的质量标准研究提供参考。方法:采用HPLC波长切换法测定不同基原鲜竹沥中的苯酚、对甲基苯酚和对乙基苯酚的含量。结果:不同基原中鲜竹沥中苯酚、对甲基苯酚和对乙基苯酚的含量相差较大,且毛竹、毛金竹以及粉绿竹的含量远大于其他5个竹种。结论:该方法准确稳定,重复性好,可为鲜竹沥的质量标准研究提供参考。Objective:To compare the Phenol、Para-methyl phenol and Para-ethyl phenol content of Xianzhuli of 8 originals and provide a reference for quality standard research of Xianzhuli.Methods:The Phenol、Para-methyl phenol and Para-ethyl phenol content in different original of Xianzhuli were analyzed by HPLC with variable wavelength.Results:The contents of phenol,p-methyl phenol and p-ethyl phenol in Xianzhuli were different from each other,and the contents of Phyllostachys pubescens Mazel ex H.de Leh.var.henonis(Mitford)Stapf ex Rendle.and Phyllostachys glauca McClure were much higher than those of the other five originals.Conclusion:This accurate,stable and reproducible method can provide reference for the quality standard research of Xianzhuli.

关 键 词：鲜竹沥 基原 高效液相色谱(HPLC) 含量比较 

分 类 号：R284.1[医药卫生—中药学]