盐酸达泊西汀联合行为训练治疗无规律性生活早泄患者的研究  

Study on dapoxetine hydrochloride combined with behavioral training in the treatment of premature ejaculation patients without regular sexual life

作　　者：刘冬梅[1] 陈小勇[1] 何国宝 雒金丽 LIU Dongmei;CHEN Xiaoyong;HE Guobao;LUO Jinli(Department of Andrology,the First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一医院男科,兰州730000

出　　处：《中国性科学》2022年第10期39-42,共4页Chinese Journal of Human Sexuality

摘　　要：目的探讨盐酸达泊西汀联合行为训练在无规律性生活早泄患者中的临床疗效。方法选取2018年3月至2020年3月兰州大学第一医院诊治的200例常年两地分居且无规律性生活的早泄患者作为研究对象。按照随机数字表法将其分为A组、B组、C组、D组,每组50例。A组只进行行为训练;B组不进行行为训练,在性生活前服用盐酸达泊西汀;C组进行行为训练,并只在性生活前服用盐酸达泊西汀;D组进行行为训练,并在行为训练前及性生活前服用盐酸达泊西汀。在治疗第8、16、24周时进行随访,评估四组的阴道内射精潜伏时间(IELT)、早泄诊断量表(PEDT)、临床总体印象变化量表(CGIC)、不良反应发生情况。结果治疗后,各组IELT均显著延长(P<0.05),且D组IELT显著长于其他组(P<0.05);各组PEDT评分均显著低于治疗前(P<0.05),且D组PEDT评分降低程度显著优于其他组(P<0.05);D组CGIC显著高于其他组(P<0.05);四组不良反应发生率比较,差异无统计学意义(P>0.05)。结论盐酸达泊西汀联合行为训练在无规律性生活早泄患者中的临床疗效优于单纯使用行为训练或盐酸达泊西汀。Objective To explore the clinical efficacy of dapoxetine hydrochloride combined with behavioral training in the treatment of premature ejaculation patients without regular sexual life.Methods 200 premature ejaculation patients who lived apart from their spouses all year round without regular sexual life and were treated in the First Hospital of Lanzhou University from March 2018 to March 2020 were selected as the research objects.They were divided into Group A,Gourp B,Group C and Group D according to the random number table method,each group of 50 patients.Group A received behavioral training only.Group B did not receive behavioral training and took dapoxetine hydrochloride before sexual life.Group C received behavioral training and took dapoxetine hydrochloride only before sexual life.Group D received behavioral training and took dapoxetine hydrochloride before behavioral training and sexual life.They were followed up in the 8 weeks,16 weeks and 24 weeks of treatment.The intravaginal ejaculation latency time(IELT),premature ejaculation diagnostic tool(PEDT),clinical global impression of change(CGIC)and adverse reactions were evaluated in all four groups.Results After treatment,the IELT of each group was significantly longer(P<0.05),and the IELT of Group D was significantly longer than that of other groups(P<0.05).The PEDT score of each group was significantly lower than before treatment(P<0.05),and the PEDT score in Group D was significantly lower than that of other groups(P<0.05).CGIC of Group D was significantly higher than that of other groups(P<0.05).There was no significant difference in incidence rate of adverse reactions among the four groups(P>0.05).Conclusions The clinical efficacy of dapoxetine hydrochloride combined with behavioral training in the treatment of premature ejaculation patients without regular sexual life is better than that of behavioral training or dapoxetine hydrochloride alone.

关 键 词：早泄 行为训练 盐酸达泊西汀 

分 类 号：R698[医药卫生—泌尿科学]