血清鳞状细胞癌相关抗原水平、高危型人乳头瘤病毒感染状态与宫颈癌术后复发的关系分析  

Relationship between serum SCCA,HR-HPV infection and postoperative recurrence of cervical cancer

作　　者：万颖 马鸿云[1] 田春花 张巧瑞 马贵霞 WAN Ying;MA Hongyun;TIAN Chunhua;ZHANG Qiaorui;MA Guixia(Department of Obstetrics and Gynecology,People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,Ningxia,China)

机构地区：[1]宁夏回族自治区人民医院妇产科,银川750002

出　　处：《中国性科学》2022年第10期102-105,共4页Chinese Journal of Human Sexuality

摘　　要：目的探讨血清鳞状细胞癌相关抗原(SCCA)水平、高危型人乳头瘤病毒(HR-HPV)感染状态与宫颈癌术后复发的关系。方法回顾性选取2017年9月至2019年12月宁夏回族自治区人民医院收治的192例宫颈癌患者作为研究对象,依据2年内患者是否复发分为复发组(n=18)和未复发组(n=174)。比较两组患者术后血清SCCA水平和HR-HPV感染状态,分析宫颈癌患者血清SCCA水平、HR-HPV感染状态与术后复发之间的关系。结果两组患者临床分期、肿瘤分化程度、肿瘤间质浸润深度和有无淋巴结转移比较,差异具有统计学意义(P<0.05);复发组患者血清SCCA阳性率和HR-HPV阳性率均高于未复发组(P<0.05)。多因素Logisitic回归分析结果显示,肿瘤低分化、深肌层浸润、SCCA阳性和HR-HPV阳性是宫颈癌患者术后复发的独立危险因素(P<0.05)。结论宫颈癌术后复发患者血清SCCA阳性率和HR-HPV阳性率均较高,两者与术后复发密切相关。Objective To explore the relationship between serum squamous cell carcinoma antigen(SCCA),high-risk human papilloma virus(HR-HPV)infection and postoperative recurrence of cervical cancer.Methods A total of 192 patients with cervical cancer admitted to People′s Hospital of Ningxia Hui Autonomous Region between September 2017 and December 2019 were retrospectively enrolled as the research objects.According to presence or absence of recurrence within 2 years,they were divided into recurrence group(n=18)and non-recurrence group(n=174).The level of serum SCCA and HR-HPV infection status between the two groups were compared after surgery.The relationship between serum SCCA,HR-HPV infection and postoperative recurrence of cervical cancer was analyzed.Results There were significant differences in clinical staging,tumor differentiation,depth of tumor interstitial infiltration and lymph node metastasis between the two groups(P<0.05).The positive rates of serum SCCA and HR-HPV in recurrence group were higher than those in non-recurrence group(P<0.05).The multivariate Logisitic regression analysis showed that low differentiation,deep myometrial infiltration,positive SCCA and HR-HPV were independent risk factors of postoperative recurrence in patients with cervical cancer.Conclusions The positive rates of serum SCCA and HR-HPV are high in patients with postoperative recurrence of cervical cancer,which are closely related to postoperative recurrence.

关 键 词：宫颈癌 复发 高危型人乳头瘤病毒 鳞状细胞癌相关抗原 

分 类 号：R711[医药卫生—妇产科学]