人工周期和自然周期内膜准备在冻融胚胎移植患者中的应用效果  

Application Effect of Artificial Cycle and Natural Cycle Intima Preparation in Patients with Frozen Embryo Transfer

作　　者：程婷婷[1] CHENG Tingting(Xuzhou Maternal and Child Health Hospital,Xuzhou 221000,China)

机构地区：[1]徐州市妇幼保健院,江苏徐州221000

出　　处：《中外医学研究》2022年第29期24-27,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:比较人工周期和自然周期内膜准备在冻融胚胎移植(FET)患者中的应用效果。方法:回顾性选取2018年6月-2020年12月徐州市妇幼保健院生殖中心行FET的76例患者作为研究对象。根据不同内膜准备方案将其分为A组(n=38)与B组(n=38)。A组给予人工周期内膜准备,B组给予自然周期内膜准备。比较两组移植日情况、胚胎复苏情况、妊娠结局。结果:B组移植日子宫内膜厚度显著大于A组,移植日血清E水平显著高于A组(P<0.05),两组移植日血清P水平及移植胚胎数比较差异均无统计学意义(P>0.05)。两组胚胎复苏成功率、完整胚胎复苏率、优胚率比较差异均无统计学意义(P>0.05)。两组生化妊娠率、临床妊娠率、多胎率、自然流产率及分娩率比较差异均无统计学意义(P>0.05)。结论:FET采用人工周期与自然周期准备子宫内膜的妊娠结局无明显差异,临床医生可根据患者的实际情况选择适宜的内膜准备方案,以增加患者的子宫内膜容受性,对于存在排卵障碍或月经周期不规律的患者,若无法确定患者移植时间,建议选择人工周期。Objective:To compare the application effect of artificial cycle and natural cycle intima preparation in patients with frozen embryo transfer (FET).Method:A total of 76 patients who underwent FET in the Reproductive Center of Xuzhou Maternal and Child Health Hospital from June 2018 to December 2020 were retrospectively selected as the research objects.They were divided into group A (n=38) and group B (n=38) according to different intimal preparation schemes.Group A was given artificial cycle intima preparation,and group B was given natural cycle intima preparation.The transfer day condition,embryo recovery condition and pregnancy outcome were compared between the two groups.Result:The endometrial thickness of transfer day of group B was significantly greater than that of group A,and the serum Elevel of transfer day was significantly higher than that of group A (P<0.05).There were no signficant differences in serum P level and number of embryos transferled between the two groups at the transfer day (P>0.05).There were no significant differences in the success rate of embryo recovery,complete embryo recovery rate and excellent embryo rate between the two groups (P>0.05).There were no significant differences in biochemical pregnancy rate,clinical pregnancy rate,multiple pregnancy rate,spontaneous abortion rate and delivery rate between the two groups (P>0.05).Conclusion:There is no obvious difference in pregnancy outcome between using artificial cycle and natural cycle to prepare endometrium in FET.Clinicians can choose an appropriate endometrial preparation scheme according to the actual situation of patients to increase the endometrial receptivity of patients.For patients with ovulation disorder or irregular menstrual cycle,if it is impossible to determine the transplant time of patients,it is recommended to choose artificial cycle.

关 键 词：冻融胚胎移植 人工周期 自然周期 内膜准备 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]