静脉注射人免疫球蛋白联合阿司匹林对川崎病患儿的影响  

Effects of Human Immunoglobulin for Intravenous Injection Combined with Aspirin on Children with Kawasaki Disease

作　　者：林美娇 崔国斌 LIN Meijiao;CUI Guobin(Putian Children’s Hospital,Putian 351100,China)

机构地区：[1]莆田市儿童医院,福建莆田351100

出　　处：《中外医学研究》2022年第30期112-115,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨静脉注射人免疫球蛋白(IVIG)联合阿司匹林对川崎病(KD)患儿的影响。方法:选取2020年5月-2022年4月莆田市儿童医院治疗的82例KD患儿。按照随机数字表法将其分为观察组和对照组,各41例。对照组给予阿司匹林,于对照组基础上,观察组加用IVIG。比较两组治疗前、治疗2周后炎症因子、免疫功能,临床症状消退时间及不良反应。结果:治疗2周后,两组CRP、TNF-α水平均较治疗前低,且观察组CRP、TNF-α水平均低于对照组(P<0.05)。治疗2周后,两组CD4^(+)、CD4^(+)/CD8^(+)均较治疗前低,CD8^(+)较治疗前高,且观察组CD4^(+)、CD4^(+)/CD8^(+)均低于对照组,CD8^(+)高于对照组(P<0.05)。观察组黏膜充血、发热、淋巴结肿大及四肢肿胀消退时间均早于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(χ^(2)=0.139,P=0.710)。结论:IVIG联合阿司匹林治疗KD患儿可抑制炎症反应,降低CRP、TNF-α水平,调节患儿的免疫功能,加快临床症状消退,且不增加不良反应。Objective:To explore the effect of Human Immunoglobulin for Intravenous Injection(IVIG)combined with Aspirin on children with Kawasaki disease(KD).Method:A total of 82 children with KD who were treated in Putian Children’s Hospital from May 2020 to April 2022 were selected.According to the method of random number table,they were divided into observation group and control group,41 cases each.The control group was given Aspirin,and the observation group added the application of IVIG on the basis of the control group.The inflammatory factors,immune function before and after treatment for 2 weeks,clinical symptom resolution time and adverse reactions were compared between the two groups.Result:After 2 weeks of treatment,the levels of CRP and TNF-αin the two groups were lower than those before treatment,and the levels of CRP and TNF-αin the observation group were lower than those in the control group(P<0.05).After 2 weeks of treatment,CD4^(+),CD4^(+)/CD8^(+)in both groups were lower than those before treatment,and CD8^(+)was higher than that before treatment,CD4^(+),CD4^(+)/CD8^(+)in the observation group were lower than those in the control group,and CD8^(+)was higher than that in the control group(P<0.05).The regression time of mucosal congestion,fever,lymph node enlargement and limb swelling in the observation group were earlier than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.139,P=0.710).Conclusion:IVIG combined with Aspirin can inhibit inflammatory reaction and reduce CRP and TNF-αlevels in KD children,regulate the immune function of children,accelerate the regression of clinical symptoms,and do not increase adverse reactions.

关 键 词：川崎病 静脉注射人免疫球蛋白 阿司匹林 炎症因子 免疫功能 

分 类 号：R725.4[医药卫生—儿科]