Nrf2在糖尿病心肌病中的作用及中药干预研究进展  

Research progress on Nrf2 in diabetic cardiomyopathy and intervention of traditional Chinese medicine

作　　者：王文娟 齐鸣瑞 田利民[2,3] WANG Wenjuan;QI Mingrui;TIAN Limin(The First Clinical Medical College,Gansu University of Traditional Chinese Medicine;Department of Endocrinology,Gansu Provincial Hospital;Gansu Clinical Research Center For Metabolic Diseases,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃中医药大学第一临床医学院 [2]甘肃省人民医院内分泌科 [3]甘肃省代谢性疾病临床医学研究中心,甘肃兰州730000

出　　处：《中国临床药理学与治疗学》2022年第10期1163-1170,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：甘肃中医药大学第一临床医学院研究生创新基金项目(LCCX2021010)。

摘　　要：糖尿病心肌病(diabetic cardiomyopathy,DCM)作为糖尿病的心血管并发症,严重影响糖尿病患者的预后。近年来,糖尿病心肌病的发病率和死亡率持续增高,成为人们重点关注的研究问题。糖尿病心肌病的发病机制复杂,多种信号通路参与其进展过程。核因子E2相关因子2(nuclear factor NF-E2-related factor 2,Nrf2)作为一种强效抗氧化基因,通过与其他信号因子相互关联增强心肌抵抗氧化应激的能力,并发挥抗炎症反应、抗心肌纤维化以及抗细胞凋亡等作用。大量研究文献显示,中药有效成分可以通过增强Nrf2的表达,影响Nrf2与其他信号因子的相互关联来改善糖尿病心肌病的心肌损伤。故本文就Nrf2在糖尿病心肌病中的作用及中药干预研究进行文献综述,为糖尿病心肌病的防治提供参考。As a cardiovascular complication of diabetes,diabetic cardiomyopathy seriously affects the prognosis of patients with diabetes.The incidence and mortality of diabetic cardiomyopathy increase,and has emerged as a research hotspot in current years.The pathogenesis of diabetic cardiomyopathy is complex,involving a range of signaling pathways in its incidence and development.Nuclear factor NF-E2-related factor 2(Nrf2),as a powerful antioxidant gene,enhances the capacity of the myocardium to withstand oxidative stress via interplay with different signaling elements and exerts anti-inflammatory response,anti-myocardial fibrosis,and anti-apoptosis effects.Researches have shown that certain ingredients of traditional Chinese medicine can alleviate the myocardial injury by affecting the relationship of Nrf2 with other signaling factors via enhancing the expression of Nrf2.Here we review the role of Nrf2 and therapy of traditional Chinese medicine in diabetic cardiomyopathy in hope of providing referential idea for the treatment of diabetic cardiomyopathy.A reference for the prevention and therapy of diabetic cardiomyopathy.

关 键 词：NRF2 糖尿病心肌病 中药 抗氧化应激 

分 类 号：R587.1[医药卫生—内分泌] R714.252[医药卫生—内科学]