重楼皂苷抗肺癌作用机制的研究进展  

Research progress in the mechanism of anti-lung cancer effect of polyphyllin

作　　者：何娜[1,2] 杨洋 朱婧 张静媚 陈琴华 杨光义 HE Na;YANG Yang;ZHU Jing;ZHANG Jing-mei;CHEN Qin-hua;YANG Guang-yi(The Seventh Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen Guangdong 518000;Shenzhen Bao’an Hospital of Authentic Traditional Chinese Medicine Therapy,Shenzhen Guangdong 518102)

机构地区：[1]广州中医药大学第七临床医学院,广东深圳518000 [2]深圳市宝安纯中医治疗医院,广东深圳518102

出　　处：《中南药学》2022年第10期2368-2373,共6页Central South Pharmacy

基　　金：广东省中医药局项目(No.20221340);深圳市科创委项目(No.JCYJ20210324142012033);深圳市“医疗卫生三名工程”项目资助(No.SZZYSM202106004)。

摘　　要：重楼皂苷是中药重楼发挥抗肺癌作用的主要活性成分。现代药理学研究表明,重楼皂苷能够通过抑制肿瘤细胞增殖生长、诱导肿瘤细胞程序性死亡、逆转肿瘤细胞耐药性、抗肿瘤细胞迁徙和侵袭、调节机体免疫等机制发挥抗肺癌作用,然而目前尚无有关重楼皂苷抗肺癌作用机制的系统梳理。本文综述了国内外有关重楼皂苷抗肺癌作用及作用机制的研究进展,为重楼皂苷的抗肺癌药物研发提供参考。Polyphyllin,the main active component in Chinese medicine Rhizoma Paridis,plays an anti-lung cancer effect.Modern pharmacological studies have shown that polyphyllin exert anti-lung cancer effect by inhibiting the proliferation and growth of tumor cells,inducing programmed death,reversing drug resistance,anti-migration and invasion,regulating body immunity and so on.However,no systematic review on the anti-lung cancer mechanism of polyphyllin was found.This paper reviewed the research progress on the anti-lung cancer effect and mechanism of polyphyllin home and abroad,providing reference for the research and development of anti-lung cancer drugs of polyphyllin.

关 键 词：重楼皂苷 肺癌 作用机制 内质网应激 PI3K通路 STAT3通路 

分 类 号：R285[医药卫生—中药学]