八角莲木脂素和黄酮类化学成分研究  

Lignans and flavonoids from the roots and rhizomes of Dysosma versipellis

作　　者：张欣[1] 曹瑞[1] 冯改利[1] 张化为[1] 姜祎 王薇[1] 邓翀 ZHANG Xin;CAO Rui;FENG Gai-li;ZHANG Hua-wei;JIANG Yi;WANG Wei;DENG Chong(School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712046)

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046

出　　处：《中南药学》2022年第9期2072-2075,共4页Central South Pharmacy

基　　金：陕西省科技厅自然科学研究基础计划项目(No.2021JQ-742);陕西中医药大学学科创新团队项目(No.2019-YL12)。

摘　　要：目的 研究八角莲中木脂素和黄酮类化学成分。方法 采用硅胶柱色谱、葡聚糖凝胶LH-20柱色谱以及半制备型高效液相色谱等方法分离,根据MS和NMR等数据鉴定化合物的结构。结果 从八角莲中共分离鉴定了5个木脂素和3个黄酮类化合物,分别为爵床脂素A(1)、山荷叶素葡萄糖苷(2)、arabelline(3)、鬼臼毒素-4-O-β-D-葡萄糖苷(4)、落叶松树脂醇-4-O-β-D-吡喃葡萄糖苷(5)、槲皮素(6)、山柰酚3-O-β-D-葡萄糖苷(7)、槲皮素-3-O-α-L-鼠李糖苷(8)。结论 化合物1、3、5和8为首次从八角莲中分离鉴定。Objective To determine the lignans and flavonoids in the roots and rhizomes of Dysosma versipellis.Methods The chemical constituents were separated by chromatography on silica gel,Sephadex LH-20 and semi-preparative HPLC.The structures were elucidated by spectroscopic methods,including MS and NMR spectral data ananlysis.Results Five lignans and three flavonoids were obtained from the roots and rhizomes of Dysosma versipellis and identified as justicidin A (1),diphyllin-4-O-β-D-glucoside (2),arabelline (3),podophyllotoxin-4-O-β-D-glucoside (4),lariciresinol-4-O-β-D-glucopyranoside (5),quercetin (6),kaempferol-3-O-β-D-glucoside (7) and quercetin-3-O-α-L-rhamnoside (8).Conclusion Compounds 1,3,5 and 8 have been isolated from Dysosma versipellis for the first time.

关 键 词：八角莲 化学成分 木脂素 黄酮 

分 类 号：R286[医药卫生—中药学]