氨基糖苷类抗生素检测技术的发展  

Development of Detection Technologies for Aminoglycoside Antibiotics

作　　者：孟飞 周小华 袁耀佐 MENG Fei;ZHOU Xiaohua;YUAN Yaozuo(Jiangsu Institute for Food and Drug Control,Nanjing 210019;Nanjing University of Chinese Medicine,Nanjing 210023;NMPA Key Laboratory for Impurity Profile of Chemical Drugs,Nanjing 210019)

机构地区：[1]江苏省食品药品监督检验研究院,南京210019 [2]南京中医药大学,南京210023 [3]国家药品监督管理局化学药物杂质谱研究重点实验室,南京210019

出　　处：《药学与临床研究》2022年第5期441-446,共6页Pharmaceutical and Clinical Research

摘　　要：综述氨基糖苷类抗生素不同检测技术及手段的最新进展。包括目前国内外药典中氨基糖苷类抗生素质量控制的主要采用了微生物检定、TLC、衍生化-UV、HPLC-ELSD、HPLCPAD等,以及近年来广泛采用的新型气溶胶检测器CAD、NQAD;开发CAD、NQAD的氨基糖苷类抗生素质量控制方法有望弥补其他检测技术的缺陷。This review briefly introduced aminoglycoside antibiotics and the development of their detection technologies.At present,the main detection methods for aminoglycoside antibiotics in pharmacopoeias at home and abroad include microbial assay,TLC,derivatization-UV,HPLC-ELSD,HPLC-PAD and so on.With the development of detection technologies,the application of new aerosol detectors CAD and NQAD are becoming more and more widespread.The development of CAD and NQAD quality control methods for aminoglycoside antibiotics can also make up for the defects of other detection technologies.

关 键 词：氨基糖苷类抗生素 高效液相色谱 药物分析 水凝聚核粒子计数蒸发光检测器 

分 类 号：R927[医药卫生—药学]