啮齿类实验动物行为学视觉测量方法  

Behavioral measurements of visualization in rodent laboratory animals

作　　者：程天 姚泰康 索玲格 张頔 张纯[2] CHENG Tian;YAO Taikang;SUO Lingge;ZHANG Di;ZHANG Chun(School of Basic Medicine Sciences,Peking University,Beijing 100191;China.2.Department of Ophthalmology,Peking University Third Hospital,Beijing 100191)

机构地区：[1]北京大学基础医学院,北京100191 [2]北京大学第三医院眼科,北京100191

出　　处：《中国实验动物学报》2022年第5期686-691,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(81970798);首都医学发展科研基金(CFH2020-2-40911)。

摘　　要：啮齿类动物广泛运用于视觉疾病的造模;为了合理评估动物模型的视觉疾病损害程度和治疗手段干预效果,需要掌握合适的啮齿类实验动物视觉检测手段。视觉行为学检测具有简明、直观、非侵入、可重复的优良特性,能够弥补其他视觉测量手段的缺陷。从定性以及定量两个角度对常用的啮齿类实验动物行为学视觉测量方法进行综述,有助于实验者选择适当的检测方法,提升动物视觉检测效率。Rodents,as important experimental animals,are exceptionally well-suited for studies of peripheral visual field diseases because of their visual structure,and are therefore key to the development of drugs related to peripheral visual field diseases.Behavioral visual measurements,including qualitative as well as quantitative measures,have the positive characteristics of being concise,intuitive,non-invasive,reproducible and can compensate for the shortcomings of other visual measures.Qualitative measures for judging vision in rodents are simple and easy to perform,including the visual placing test,the visual cliff test,and looming visual stimuli.By contrast,quantitative measures such as a water maze and the visual water task can accurately measure the visual acuity of rodents.This review provides a reference for researchers using rodents as experimental animals for visual studies.In addition,it provides valuable information to select appropriate modeling method and behavioral tests according to the purpose of the study,which will help experimenters to improve the efficiency of animal vision detection by selecting appropriate tests.

关 键 词：啮齿类动物 视觉测量 行为学 

分 类 号：Q95-33[生物学—动物学]