用于疫苗温度标签的共轭二乙炔类单体  

Conjugated Diacetylene Monomers for Vaccine Vial Monitor

作　　者：白杏茹 朱光明[1] 郝瑜佳 BAI Xing-Ru;ZHU Guang-ming;HAO Yu-jia(School of Chemistry and Chemical Engineering,Northwestern Polytechnical University,Xi'an 710129,China)

机构地区：[1]西北工业大学化学与化工学院,西安710129

出　　处：《包装工程》2022年第21期112-122,共11页Packaging Engineering

摘　　要：目的疫苗在生产运输过程中受到温度、辐射等因素会影响其效价,共轭二乙炔类疫苗温度标签能够将这些影响因素与疫苗稳定性紧密联系起来,进一步促进其在疫苗温度标签中的应用提供参考和理论借鉴。方法首先对共轭二乙炔类单体的固相聚合机理和可发生固相聚合的单体结构进行简单分类和归纳,其次对可引起共轭二乙炔类单体聚合速率改变的因素进行总结,然后将共轭二乙炔类单体作为疫苗温度标签的研究现状和应用情况进行概述,最后对我国应用共轭二乙炔类疫苗温度标签存在的问题和未来发展方向进行分析和展望。结果挑选聚合中能有明显变色的共轭二乙炔类单体,以及添加不同种类的自由基引发剂,以调节共轭二乙炔单体的聚合速率,来匹配不同产品的保质期以及运输需求。结论共轭二乙炔类疫苗温度标签能够更好地指示疫苗的有效性,也可大大减少我国疫苗出口成本。Vaccines are subject to temperature,radiation and other factors during production and transportation,which will affect their titers.The conjugated diacetylene Vaccine Vial Monitor(VVM)can closely link these influencing factors with vaccine stability,so as to provide theoretical references for its application in VVM.This paper briefly expounds the solid-phase polymerization mechanism of conjugated diacetylene,and the structural requirements of conjugated diacetylene monomers that can undergo solid-phase polymerization.Besides the factors that can cause the change of polymerization rate of conjugated diacetylene monomer are summarized.Then,the research status and application of conjugated diacetylene monomers as VVM are summarized.Finally,the existing problems and future development directions of conjugated diacetylene monomer based on VVM in our country are analyzed and prospected.By selecting conjugated diacetylene monomers with obvious discoloration during polymerization,and adding different kinds of free radical initiators,the polymerization rate of conjugated diacetylene monomers can be adjusted to match the shelf life and transportation requirements of different products.This type of label better indicates the effectiveness of vaccines and can also greatly reduce the cost of our country's vaccine exports.

关 键 词：共轭二乙炔 固相聚合机理 聚合速率 疫苗温度标签 评述 

分 类 号：TQ460.69[化学工程—制药化工]