慢性乙型肝炎患者HBeAg血清学转换影响因素的研究进展  

Influencing factors for HBeAg seroconversion in patients with chronic hepatitis B

作　　者：顾子杨 王安辉 何文昌 李佳玉 黄长形 GU Ziyang;WANG Anhui;HE Wenchang;LI Jiayu;HUANG Changxing(Department of Infectious Diseases,The Second Affiliated Hospital of Air Force Medical University,Xi’an 710038,China;Department of Epidemiology,School of Military Preventive Medicine,Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学第二附属医院传染病科,西安710038 [2]空军军医大学军事预防医学系流行病学教研室,西安710032

出　　处：《临床肝胆病杂志》2022年第11期2581-2585,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(81872670)。

摘　　要：HBeAg血清学转换是指既往HBeAg阳性的慢性乙型肝炎(CHB)患者HBeAg消失,抗-HBe出现。HBeAg血清学转换标志着病毒复制降低、免疫耐受减弱和肝脏炎症减轻,是评估病情和评价CHB抗病毒治疗效果的重要监测指标,预示着治疗满意的终点。探索影响HBeAg血清学转换的不同因素,对CHB患者治疗方案的选择以及预后评估意义重大。本综述主要就HBV病毒学因素、宿主遗传因素、药物因素、免疫学因素等方面与CHB患者发生HBeAg血清学转换的关系展开阐述。HBeAg seroconversion refers to the disappearance of HBeAg and the appearance of anti-HBe in chronic hepatitis B(CHB)patients with positive HBeAg in the past.HBeAg seroconversion marks the reductions in viral replication,immune tolerance,and liver inflammation and is an important monitoring indicator for evaluating disease conditions and the effect of CHB antiviral therapy,and it also indicates the endpoint of satisfactory treatment.Exploring the influencing factors for HBeAg seroconversion is of great significance to the selection of treatment regimens and the prognostic evaluation of CHB patients.This article mainly elaborates on the association of HBV with HBeAg seroconversion in CHB patients from the aspects of virological factors,host genetic factors,drug factors,and immunological factors.

关 键 词：乙型肝炎 慢性 乙型肝炎E抗原 影响因素 

分 类 号：R512.62[医药卫生—内科学]