肝细胞极性调控  

Regulation of hepatocyte polarity

作　　者：毛元鹏 魏红山[1,2] MAO Yuanpeng;WEI Hongshan(Department of Gastroenterology,Peking University Ditan Teaching Hospital,Beijing 100015,China;Department of Gastroenterology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]北京大学地坛医院教学医院消化科,北京100015 [2]首都医科大学附属北京地坛医院消化科,北京100015

出　　处：《临床肝胆病杂志》2022年第11期2654-2658,共5页Journal of Clinical Hepatology

基　　金：北京市医院管理中心消化内科学科协同发展中心专项(XXZ0404);北京市自然科学基金(7202071);国家自然科学基金(82170541)。

摘　　要：肝细胞是高度极化的细胞。肝细胞极性的建立和维持对肝细胞的诸多功能至关重要。肝细胞极性的动态稳定与诸多因素相关,包括细胞间连接、极性蛋白复合体以及多个信号通路。当极性受到破坏,肝细胞功能往往出现异常,最终可能导致各类肝脏疾病的发生。目前,关于肝细胞极性调控相关研究仍然较少,多种关键因素尚未得到完全阐明。本文简要介绍了近年来肝细胞极性调控相关研究进展。Hepatocytes are highly polarized cells,and the establishment and maintenance of hepatocyte polarity are critical for the various functions of hepatocytes.The dynamic stability of hepatocyte polarity is associated with various factors including intercellular junctions,polarity complex proteins,and several signaling pathways.Abnormal hepatocyte function is often observed when polarity gets destroyed,which may eventually lead to various liver diseases.At present,there are still a few studies on the regulation of hepatocyte polarity,and many key factors have not been fully elucidated.This article briefly introduces the recent research advances in the regulation of hepatocyte polarity.

关 键 词：肝疾病 肝细胞 细胞极性 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]