老年代谢综合征患者预后情况与血清钙、游离脂肪酸水平的相关性分析  

Prognosis of elderly patients with metabolic syndrome and its correlation with serum calcium and free fatty acid levels

作　　者：郭兴梁 刘芙蓉[2] GUO Xing-liang;LIU Fu-rong(Laboratory Department of Bazhong Central Hospital,Bazhong,Sichuan 636000,China;Department of Cardiology,Bazhong Central Hospital,Bazhong,Sichuan 636000,China)

机构地区：[1]四川省巴中市中心医院检验科,四川巴中636000 [2]四川省巴中市中心医院心内科,四川巴中636000

出　　处：《公共卫生与预防医学》2022年第6期98-101,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的分析老年代谢综合征(MS)患者预后情况与血清钙、游离脂肪酸水平的相关性,为临床分析MS患者临床预后提供理论依据。方法研究分析2019年12月1日至2020年12月1日期间符合代谢综合征诊断标准的65岁以上就诊患者,共纳入579例受试对象。收集受试对象相关社会人口学信息,测定BMI值、血清钙及游离脂肪酸水平、血压、血糖和血脂等水平;随访1年至2021年12月1日,统计MS患者预后情况、MS患者发生缺血性脑卒中、出血性脑卒中、冠心病等情况,根据MS患者预后情况分为不良预后组和预后良好组。采用多因素logistic回归分析MS患者不良预后的危险因素;采用Pearson相关性分析讨论血清钙及游离脂肪酸水平与MS患者预后的相关性分析。结果随访1年,579例MS患者不良预后共108例(18.65%),两组在LDL-C、HDL-C、SBP、FBG、HbA1c、Ca、FFA方面比较,差异具有统计学意义(P<0.05);回归分析提示,男性(OR=1.952),肥胖(OR=2.088)、SBP异常增高(OR=2.828)、HbA1c水平异常增高(OR=3.022)、血清钙水平异常增高(OR=4.798)、血清游离脂肪酸水平异常增高(OR=5.803)为MS患者不良预后的危险因素(P<0.05);MS患者不良预后与血清钙及游离脂肪酸水平呈正相关(r=0.472,0.458,P<0.05)。结论老年MS患者血清钙和游离脂肪酸水平异常是发生不良预后的危险因素,临床上应给予积极预防,可改善MS患者预后。Objective To analyze the prognosis of elderly patients with metabolic syndrome(MS)and its correlation with serum calcium and free fatty acid levels,so as to provide theoretical basis for clinical analysis of the prognosis of MS patients.Methods A total of 579 patients over 65 years old who met the diagnostic criteria of metabolic syndrome from December 1,2019 to December 1,2020 were included.The relevant social demographic information of subjects was collected,and BMI,serum calcium and free fatty acid levels,blood pressure,blood glucose and lipid levels were determined.The patients were followed up for 1 year to December 1,2021,and the prognosis of MS patients was analyzed,including the occurrence of ischemic stroke,hemorrhagic stroke and coronary heart disease.According to the prognosis of MS patients,they were divided into poor prognosis group and control group.Multivariate logistic regression was used to analyze the risk factors for poor prognosis of MS patients.Pearson correlation analysis was used to discuss the correlation between serum calcium and free fatty acid levels and prognosis of MS patients.Results After one year follow-up,108 cases(18.65%)of 579 MS patients had poor prognosis.There were statistically significant differences in LDL-C,HDL-C,SBP,FBG,HbA1c,Ca and FFA between the two groups(P<0.05).Regression analysis suggested that male(OR=1.952),Obesity(OR=2.088),abnormal increase of SBP(OR=2.828),abnormal increase of HbA1c level(OR=3.022),abnormal increase of serum calcium level(OR=4.798),abnormal increase of serum free fatty acid level(OR=5.803)were the risk factors for poor prognosis of MS patients(P<0.05).The adverse prognosis of MS patients was positively correlated with serum calcium and free fatty acid levels(r=0.472,0.458,P<0.05).Conclusion Abnormal serum calcium and free fatty acid levels in elderly patients with metabolic syndrome are risk factors for poor prognosis of MS patients,and active prevention should be given in clinic to improve the prognosis of MS patients.

关 键 词：老年 血清钙水平 血清游离脂肪酸水平 分布 关联 

分 类 号：R181[医药卫生—流行病学]