亚临床甲状腺功能减退对2型糖尿病发生风险的影响  

Influence of subclinical hypothyroidism on risk of type 2 diabetes mellitus and its related factors

作　　者：李永桂 李小鸾[1] 杨历新[1] LI Yong-gui;LI Xiao-luan;YANG Li-xin(Department of Endocrinology,Qinghai Provincial People′s Hospital,Xining,Qinghai 810007,China)

机构地区：[1]青海省人民医院内分泌一科,青海西宁810007

出　　处：《公共卫生与预防医学》2022年第6期152-155,共4页Journal of Public Health and Preventive Medicine

基　　金：青海省科技计划项目(2020-ZJ-930)。

摘　　要：目的探讨亚临床甲状腺功能减退对2型糖尿病(T2DM)发生风险的影响。方法将2019年1月至2021年12月期间青海省人民医院接诊的T2DM患者共计71例(病例组),选取同时间段78例健康体检者纳入研究(对照组),所选病例均实行过甲状腺功能检测。收集患者确诊糖尿病前的甲状腺功能信息及潜在影响因素情况,潜在影响因素包含性别、年龄、常见慢性病家族史、并发常见慢性病情况、吸烟饮酒史以及BMI水平、血压及血脂水平等。结果单因素分析可见病例组患者比对照组甲状腺功能异常(亚临床甲状腺功能减退)者、女性、年龄、血压异常、血脂异常和糖尿病家族史所占比例更高,多因素回归模型,最终提示女性(OR=1.121),血脂异常(OR=1.140),甲状腺功能异常(亚临床甲状腺功能减退)(OR=1.423),以及糖尿病家族史(OR=1.110)4个因素为潜在增加T2DM发生风险的危险因素(P<0.05)。结论存在亚临床甲状腺功能减退以及血脂异常的女性,同时具有糖尿病家族史者,发生T2DM的风险增高,值得临床关注并予以相关预防措施。Objective To explore the effect of subclinical hypothyroidism on the risk of type 2 diabetes mellitus(T2DM),and to conduct multivariate analysis in order to prevent it.Methods A total of 71 T2DM patients(case group)and 78 non-diabetic patients(control group)were enrolled in the study in January 2019-2021 December.Collect thyroid function information and potential influence factors before diagnosis of diabetes mellitus.Potential influencing factors include gender,age,family history of common chronic diseases,complications of common chronic diseases,smoking and drinking history,BMI level,blood pressure and blood lipid level.Results Univariate analysis showed that the proportion of patients with abnormal thyroid function(subclinical hypothyroidism),female,age,abnormal blood pressure,dyslipidemia and family history of diabetes was higher in case group than in control group.Multivariate regression model indicated that female(OR=1.121),dyslipidemia(OR=1.140),thyroid dysfunction(subclinical hypothyroidism)(OR=1.423)were the final indication.And family history of diabetes(OR=1.110)is the four risk factor to increase the risk of T2DM(P<0.05).Conclusion Women with subclinical hypothyroidism and dyslipidemia,who have family history of diabetes,have higher risk of T2DM.It is worthy of clinical attention and relevant preventive measures.

关 键 词：亚临床甲状腺功能减退 2型糖尿病 病例对照 

分 类 号：R181[医药卫生—流行病学]