沃尔巴克氏体控制媒介伊蚊的应用及前景  

Application and Prospect of Wolbachia for Aedes for Mosquito Vector Control

作　　者：龚君淘 刘起勇[2] 王以燕 洪晓月[4] 奚志勇 Gong Juntao;Liu Qiyong;Wang Yiyan;Hong Xiaoyue;Xi Zhiyong(Guangzhou Wolbaki Institute of Biological Research,Guangzhou Guangdong 510535,China;State Key Laboratory of Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,WHO Collaborating Centre for Vector Surveillance and Management,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Institute for the Control of Agrochemicals,Ministry of Agriculture and Rural Affairs,Beijing 100125,China;College of Plant Protection,Nanjing Agricultural University,Nanjing jiangsu 210095,China;Department of Microbiolog y and Molecular Genetics,Michigan State University,East Lansing,MI 48824,USA)

机构地区：[1]广州威佰昆生物研究院,广东广州510535 [2]中国疾病预防控制中心传染病预防控制所媒介生物控制室,传染病预防控制国家重点实验室,感染性疾病诊治协同创新中心,世界卫生组织媒介生物监测与管理合作中心,北京102206 [3]农业农村部农药检定所,北京100125 [4]南京农业大学植物保护学院,江苏南京210095 [5]密歇根州立大学,美国东兰辛MI 48824

出　　处：《农药科学与管理》2022年第10期20-29,共10页Pesticide Science and Administration

摘　　要：近年来,沃尔巴克氏体作为一种新型微生物农药,已在世界多地蚊媒疾病流行地区的蚊媒防控现场崭露头角。沃尔巴克氏体在宿主媒介伊蚊体内诱导不育和抗病特性,使其在应用中产生种群压制和种群替换两种不同的防治模式。本文综述了近年世界范围采用这两种防治模式释放人工转染媒介伊蚊(埃及伊蚊和白纹伊蚊)研究转化及现场应用经验,评估在应用中生物安全风险及经济效益,并展望此技术在未来蚊媒疾病防控相关公共卫生领域的应用潜力。The maternally inherited endosymbiotic bacterium Wolbachia has recently emerged as a novel microbial pesticide for mosquito-borne disease control in endemic areas around the world.The ability of Wolbachia to induce conditional sterility and pathogen blocking in mosquitoes enables to development of two different vector control strategies:population suppression and population replacement.This paper describes and discusses these two strategies'translational research and field application in releasing the artificially transinfected Aedes aegypti and Aedes albopictus in recent decades.Furthermore,the current evidence on the biosafety and economic benefits of the Wolbachia technology is reviewed and the potential of its area-wide application for sustainable vector management of mosquito vectors is highlighted.

关 键 词：沃尔巴克氏体 伊蚊 种群压制 种群替换 微生物农药 风险和效益 

分 类 号：S482[农业科学—农药学]