胺碘酮治疗老年重度心力衰竭合并快速心律失常的效果评价  

Evaluation of effect of amiodarone in the treatment of elderly patients with severe heart failure and tachyarrhythmia

作　　者：唐晓楠 TANG Xiao-nan(Department of Cardiology,Liaojian Group Shenmei General Hospital,Shenyang 110122,China)

机构地区：[1]辽健集团沈煤总医院心内科,110122

出　　处：《中国现代药物应用》2022年第19期99-101,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 探究老年重度心力衰竭合并快速心律失常应用胺碘酮治疗的临床效果。方法 90例老年重度心力衰竭合并快速心律失常患者作为研究对象,按照随机数字表法分为对照组和研究组,各45例。对照组采用常规对症治疗,研究组在常规基础上采用胺碘酮治疗。对比两组临床疗效、不良反应发生情况及治疗前后心功能指标[左室舒张末期内径(LVEDD)、心脏指数(CI)及左室射血分数(LVEF)]。结果 研究组治疗总有效率95.56%高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗前,两组LVEDD、CI及LVEF对比,差异无统计学意义(P>0.05);治疗后,两组LVEDD、CI及LVEF均优于治疗前,且研究组LVEDD(43.10±6.07)mm、CI(2.95±0.57)L/(min·m2)及LVEF(50.41±7.20)%均优于对照组的(52.19±8.03)mm、(2.29±0.49)L/(min·m2)、(37.19±6.07)%,差异有统计学意义(P<0.05)。研究组不良反应发生率4.44%低于对照组的17.78%,差异有统计学意义(P<0.05)。结论 胺碘酮治疗老年重度心力衰竭合并快速心律失常可取得满意效果,可有效促进心功能恢复,保障患者治疗安全,其为理想的治疗方法。Objective To investigate the clinical effect of amiodarone in the treatment of elderly patients with severe heart failure and tachyarrhythmia.Methods A total of 90 elderly patients with severe heart failure and tachyarrhythmia as study subjects were divided into control group and research group according to random numerical table,with 45 cases in each group.The control group was treated with conventional treatment,and the research group was treated with amiodarone on the basis of conventional treatment.The clinical efficacy,occurrence of adverse reactions,and cardiac function[left ventricular end-diastolic diameter(LVEDD),cardiac index(CI)and left ventricular ejection fraction(LVEF)]before and after treatment.Results The total effective rate 95.56%of the research group was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in LVEDD,CI and LVEF between the two groups(P>0.05).After treatment,the LVEDD,CI and LVEF in both groups were better than those before treatment in this group;the LVEDD(43.10±6.07)mm,CI(2.95±0.57)L/(min·m2)and LVEF(50.41±7.20)%in the research group were better than(52.19±8.03)mm,(2.29±0.49)L/(min·m2)and(37.19±6.07)%in the control group;the differences were all statistically significant(P<0.05).The incidence of adverse reactions 4.44%in the research group was lower than 17.78%in the control group,and the difference was statistically significant(P<0.05).Conclusion Amiodarone can achieve satisfactory results for elderly patients with severe heart failure and tachyarrhythmia,effectively promote the recovery of cardiac function,and ensure the safety of patients,which can be used as an ideal treatment method.

关 键 词：重度心力衰竭 快速心律失常 胺碘酮 心功能 不良反应 

分 类 号：R541[医药卫生—心血管疾病]