左炔诺孕酮宫内节育系统治疗子宫腺肌病的疗效研究  

Efficacy of levonorgestrel intrauterine system in the treatment of adenomyosis

作　　者：王春梅[1] WANG Chun-mei(Birth Control Department,Sujiatun District Maternity and Infant Hospital,Shenyang 110101,China)

机构地区：[1]沈阳市苏家屯区妇婴医院节育科,110101

出　　处：《中国现代药物应用》2022年第19期141-143,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 研究左炔诺孕酮宫内节育系统治疗子宫腺肌病的疗效和安全性。方法 80例子宫腺肌病患者作为研究对象,按照治疗方法的不同分为对照组与观察组,每组40例。对照组采用孕三烯酮治疗,观察组采用放置左炔诺孕酮宫内节育系统治疗。比较两组患者治疗前后血清激素水平[促卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))]、子宫体积、月经量、痛经程度及不良反应发生情况。结果 治疗后,观察组FSH、LH、E_(2)水平分别为(5.68±0.83)mIU/ml、(5.05±1.03)mIU/ml、(149.20±12.04)pmol/L,均低于对照组的(6.92±0.85)mIU/ml、(6.18±1.16)mIU/ml、(168.79±13.76)pmol/L,差异均有统计学意义(P<0.05)。治疗后,观察组子宫体积、月经量及痛经程度分别为(133.92±20.46)cm3、(42.06±20.39)ml、(1.76±0.23)分,均优于对照组的(147.75±22.85)cm3、(60.48±21.48)ml、(3.53±0.42)分,差异均有统计学意义(P<0.05)。观察组不良反应发生率7.50%低于对照组的25.00%,差异有统计学意义(P<0.05)。结论 左炔诺孕酮宫内节育系统治疗子宫腺肌病疗效确切,能有效改善患者的各项临床症状,且不良反应发生率低,值得临床推广应用。Objective To study the efficacy and safety of levonorgestrel intrauterine system in the treatment of adenomyosis.Methods A total of 80 patients with adenomyosis were selected as the research subjects,and were divided into control group and observation group according to different treatment methods,with 40 cases in each group.The control group was treated with gestrinone,and the observation group was treated with levonorgestrel intrauterine system.Both groups were compared in terms of serum hormone levels[folliclestimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2)]before and after treatment,uterine volume,menstrual volume,dysmenorrhea degree and occurrence of adverse reactions.Results After treatment,the levels of FSH,LH and E2 in the observation group were(5.68±0.83)mIU/ml,(5.05±1.03)mIU/ml and(149.20±12.04)pmol/L,which were lower than(6.92±0.85)mIU/ml,(6.18±1.16)mIU/ml and(168.79±13.76)pmol/L in the control group,and the differences were all statistically significant(P<0.05).After treatment,the uterine volume,menstrual volume and dysmenorrhea degree of the observation group were(133.92±20.46)cm3,(42.06±20.39)ml and(1.76±0.23)points,which were better than(147.75±22.85)cm3,(60.48±21.48)ml and(3.53±0.42)points of the control group,and the differences were all statistically significant(P<0.05).The incidence of adverse reactions 7.50%in the observation group was lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Levonorgestrel intrauterine system is effective in the treatment of adenomyosis,and can effectively improve the clinical symptoms of patients with low incidence of adverse reactions,which is worthy of promotion and application.

关 键 词：左炔诺孕酮宫内节育器 子宫腺肌病 疗效 安全性 不良反应 

分 类 号：R711.71[医药卫生—妇产科学]