慢性乙型肝炎患者血清HBV-LP、PreS1、HMGB1水平与HBV-DNA水平的相关性  

Correlations among serum levels of HBV-LP, PreS1, HMGB1 and HBV-DNA in patients with chronic hepatitis B

作　　者：林海霞 刘颖 林璐 李玉凤 谢玉娜 LIN Haixia;LIU Ying;LIN Lu;LI Yufeng;XIE Yuna(Department of Clinical Laboratory of Longyan People’s Hospital,Longyan 361000 Fujian,China)

机构地区：[1]龙岩市人民医院检验科,福建龙岩361000

出　　处：《中国民康医学》2022年第19期105-107,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨慢性乙型肝炎(CHB)患者血清病毒外膜大蛋白(HBV-LP)、前S1抗原(Pre S1)、高迁移率族蛋白B1(HMGB1水平与乙肝病毒脱氧核糖核酸(HBV-DNA)水平的相关性。方法:选取2019年1月至2020年1月该院收治的519例CHB患者进行前瞻性研究,按照HBV-DNA载量不同分为低水平(HBV-DNA<10^(3)拷贝/mL)组185例、中水平(10^(3)~10^(7)拷贝/mL)组206例、高水平(>10^(7)拷贝/mL)组128例。比较三组肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)]、HBV-LP、PreS1、HMGB1水平,采用Pearson相关性分析ALT、AST、HBV-LP、PreS1、HMGB1水平与HBV-DNA水平的相关性。结果:低水平组ALT、AST水平低于中水平组、高水平组,且中水平组低于高水平组,差异均有统计学意义(P<0.05);三组HMGB1水平比较,差异均无统计学意义(P>0.05);低水平组HBV-LP、PreS1水平低于中水平组、高水平组,且中水平组低于高水平组,差异有统计学意义(P<0.05);Pearson相关分析结果显示,ALT、AST、HBV-LP、PreS1水平与HBV-DNA水平均呈正相关性(r>0,P<0.05)。结论:CHB患者HBV-LP、PreS1和HMGB1水平与HBV-DNA水平均呈正相关性。Objective: To investigate correlations among serum hepatitis b virus large envelope protein (HBV-LP), pre-S1 antigen (Pre S1), high mobility group protein B1 (HMGB1) levels and hepatitis B virus deoxyribonucleic acid (HBV-DNA) level in patients with chronic hepatitis B (CHB). Methods: A prospective study was conducted on 519 patients with CHB admitted to the hospital from January 2019 to January 2020. According to the different levels of HBV-DNA load, they were divided into low level (HBV-DNA<10^(3) copies/mL) group, medium level (10^(3)-10^(7) copies/mL) group and high level (>10^(7 )copies/mL) group. The levels of liver function indexes [alanine aminotransferase (ALT), aspartate aminotransferase (AST)] and the levels of HBV-LP, PreS1 and HMGB1 were compared among the three groups. The correlations among the ALT, AST, HBV-LP, PreS1, HMGB1 levels and the HBV-DNA level were analyzed by Pearson correlation analysis. Results: The levels of ALT and AST in the low level group were lower than those in the medium level group and the high level group, those of the medium level group was lower than those of the high level group, and the differences were statistically significant (P<0.05). There were no statistical differences in the HMGB1 levels among the three groups. The HBV-LP and PreS1 levels in the low level group were lower than those in the medium level group and the high level group, those of the medium level group was lower than those of the high level group, and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that the ALT, AST, HBV-LP, PreS1 levels were positively correlated with the HBV-DNA level (r>0, P<0.05). Conclusions: The levels of HBV-LP, PreS1 and HMGB1 are positively correlated with the HBV-DNA level in the CHB patients.

关 键 词：慢性乙型肝炎 乙型肝炎病毒外膜大蛋白 前S1抗原 高迁移率族蛋白B1 乙肝病毒脱氧核糖核酸 相关性 

分 类 号：R446.1[医药卫生—诊断学]