腰臀比是残余SYNTAX评分的独立危险因素  

Waist-to-hip ratio is an independent risk factor for residual SYNTAX score

作　　者：徐玲[1] 张瑞涛[1] 杨林承[1] 王雅亭 徐东晓[1] 童素梅[1] 朱丹[1] 唐熠达 XU Ling;ZHANG Rui-tao;YANG Lin-cheng;WANG Ya-ting;XU Dong-xiao;TONG Su-m ei;ZHU Dan;TANG Yi-da(Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China)

机构地区：[1]北京大学第三医院心内科,血管医学研究所,国家卫生健康委心血管分子生物学与调节肽重点实验室,分子心血管学教育部重点实验室,心血管受体研究北京市重点实验室,北京100191

出　　处：《中国介入心脏病学杂志》2022年第10期734-740,共7页Chinese Journal of Interventional Cardiology

基　　金：朱丹,北大医学青年科技创新培育基金(BMU2022PY026)。

摘　　要：目的探讨腰臀比等肥胖相关指标与冠状动脉病变的关系。方法回顾性收集2020年10月至2021年4月北京大学第三医院心血管代谢门诊患者的临床资料,包括其肥胖相关参数及冠状动脉影像学结果,评价腰臀比等肥胖相关指标与冠状动脉病变严重程度的关系。结果共纳入就诊于心血管代谢门诊患者342例,发现未合并冠状动脉病变的患者腰臀比高于合并冠状动脉病变者,但在冠心病患者中伴随冠状动脉病变支数增加,腰臀比有升高趋势(P=0.001)。后以残余SYNTAX评分作为冠状动脉遗留病变的评价指标,发现腰臀比(OR 2.507,95%CI 1.053~5.966,P=0.014)、腰围(OR 2.273,95%CI 1.033~5.378,P=0.024)、糖尿病史(OR 1.824,95%CI 1.099~3.027,P=0.002)与残余SYNTAX评分独立相关。结论不同冠状动脉病变支数受试者腰臀比分布存在差异,冠心病患者中冠状动脉病变支数与腰臀比独立相关,同时腰臀比是冠心病患者冠状动脉残余病变严重程度的独立危险因素。上述结果为进一步明确肥胖相关参数与冠状动脉病变之间的关系提供了依据。Objective To explore the relationship between waist-to-hip ratio(WHR)and other obesity-related indicators with the severity of coronary artery residual lesions.Methods Clinical data of patients in the Cardio-metabolic Clinics of Peking University Third Hospital between October2020 and April 2021 were collected,including the obesity-related indicators and the coronary imaging results.The above information was used to evaluate the relationship between obesity-related indicators such as WHR and the severity of coronary artery disease through statistical methods.Results A total of342 patients were enrolled.It was found that the WHR of patients without coronary artery disease(CHD)was higher than that of patients with CHD,however,the WHR tends to increase with the increase in the number of diseased coronary arteries(P=0.001).The residual SYNTAX score was used as the evaluation method for coronary artery lesions which showed that WHR(OR 2.507,95%CI 1.053–5.966,P=0.014),waist circumference(OR 2.273,95%CI 1.033–5.378,P=0.024)and the history of diabetes mellitus(OR 1.824,95%CI 1.099–3.027,P=0.002)were independent risk factors for residual SYNTAX score.Conclusions There were diff erences in WHR distribution among subjects with diff erent number of diseased coronary arteries.For patients with CHD,WHR was independently correlated with the number of coronary artery lesions.Furthermore,WHR was an independent risk factor for the severity of coronary artery residual disease in patients with CHD.The results provide a basis for further clarifying the relationship between obesity-related parameters and CHD.

关 键 词：冠状动脉性心脏病 腰臀比 残余SYNTAX评分 

分 类 号：R541[医药卫生—心血管疾病]