靶向甲型流感病毒血凝素的人源单克隆抗体研究进展  

Recent advances in human monoclonal antibodies targeting influenza A virus hemagglutinin

作　　者：王春颖[1] 李延柏 尹哲 霍珊珊 于飞[2,3] WANG Chunying;LI Yanbai;YIN Zhe;HUO Shanshan;YU Fei(Baoding Maternal and Child Health Hospital,Baoding 071066,China;College of Life Sciences,Hebei Agricultural University,Baoding 071001,China;Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism,Baoding 071001,China)

机构地区：[1]保定市妇幼保健院,河北保定071066 [2]河北农业大学生命科学学院,河北保定071001 [3]河北省人畜共患病原微生物分析与防控重点实验室,河北保定071001

出　　处：《河北农业大学学报》2022年第5期113-121,F0002,共10页Journal of Hebei Agricultural University

基　　金：国家自然科学基金项目(81974302);河北省杰出青年基金项目(H2021204001);保定市科技计划项目(2172P008);河北省教育厅科学技术研究项目(QN2021071).

摘　　要：甲型流感病毒感染性强,宿主广泛,主要感染禽类,其次为哺乳动物。当跨物种传染事件发生时,有可能造成流感大流行,因此,对病毒实施及时有效的监控,以及研发抗流感病毒药物刻不容缓。流感病毒表面的糖蛋白血凝素在病毒入侵宿主细胞的过程中发挥了关键的作用,可作为单克隆抗体药物的主要靶点。针对血凝素的单克隆抗体能够有效抑制病毒传播,保护宿主。因此,本文综述了目前报道的针对甲型流感病毒血凝素糖蛋白的人单克隆抗体,为后续抗流感药物的研发提供新的思路和展望。Influenza A viruses are highly infectious and have a wide range of hosts,including mainly avian and,to a lesser extent,mammalian species.When cross-species transmission events occur,there is a possibility of an influenza pandemic outbreak,and therefore it is urgent to take timely and effective surveillance of the virus as well as develop anti-influenza virus drugs.Hemagglutinin,a glycoprotein on the surface of influenza viruses,plays a key role in the process of virus invasion into host cells and can serve as a stable drug target.Monoclonal antibodies against hemagglutinin can effectively inhibit virus transmission and protect the host.Therefore,this paper reviews the currently reported human monoclonal antibodies against the hemagglutinin glycoprotein of influenza A virus to provide new ideas and prospects for the subsequent development of anti-influenza drugs.

关 键 词：流感病毒 呼吸道病毒 血凝素 单克隆抗体 作用机制 

分 类 号：S852.4[农业科学—基础兽医学] R392[农业科学—兽医学]