催乳素及血管抑制素对哺乳动物卵泡发育的调控作用研究进展  

Research Progress on the Regulation of Prolactin and Vasoinhibin on Follicular Development in Mammals

作　　者：谢社风 高凤磊[2] 李菊 韩贝贝 李承德 卫恒习 XIE Shefeng;GAO Fenglei;LI Ju;HAN Beibei;LI Chengde;WEI Hengxi(National Engineering Research Center for Swine Breeding Industry,Guangdong Provincial Key Lab of Agro-animal Genomics and Molecular Breeding,College of Animal Science,South China Agricultural University,Guangdong Guangzhou 510642,China;School of Tropical Agriculture and Forestry,College of Guangdong Agriculture Industry Business Polytechnic,Guangdong Guangzhou,510507,China;Maoming Branch,Guangdong Laboratory for Lingnan Modern Agriculture,Guangdong Maoming 525000,China)

机构地区：[1]华南农业大学动物科学学院,国家生猪种业工程技术研究中心,广东省农业动物基因组学与分子育种重点实验室,广东广州510642 [2]广东农工商职业技术学院热带农林学院,广东广州510507 [3]岭南现代农业科学与技术广东省实验室茂名分中心,广东茂名525000

出　　处：《中国畜牧杂志》2022年第10期107-113,共7页Chinese Journal of Animal Science

基　　金：广东省自然科学基金(2020A1515010976);广东省本土创新团队项目(2019BT02N630)。

摘　　要：哺乳动物卵泡发育主要受到卵巢轴生殖激素的调控。催乳素(PRL)作为经典的生殖激素可通过内分泌途径调控卵泡发育,也可以作为细胞因子对卵泡发育起局部调控作用。高水平的PRL能够抑制促性腺激素释放激素(GnRH)和黄体生成素(LH)等激素分泌,从而抑制卵泡发育。近期研究表明,PRL具有促进血管发生的功能,对有腔卵泡发育具有促进作用;而PRL经组织蛋白酶(CTSD、BMP-1和MMPs)裂解可产生血管抑制素(Vi),PRL/Vi的相对水平对血管发生起到重要影响。本文主要对PRL及Vi的结构、分泌、作用机制及其在哺乳动物卵泡发育过程中可能的调节作用进行综述,可为探究动物卵泡发育的调控机制提供参考。Follicular development in mammals is mainly regulated by reproductive hormones on the ovarian axis. Prolactin(PRL) as a classical reproductive hormone, can regulate follicular development through endocrine pathway and also play a local role in follicular development as a cytokine. High level of PRL inhibits secretion of hormones such as GnRH and LH,which in turn inhibits follicular development. Recent studies have shown that PRL has the function of promoting angiogenesis and promoting the antral follicles development. In addition, the cleavage of PRL by cathepsin(CTSD, BMP-1 and MMPs)can produce vasoinhibin(Vi), and the ratio of PRL/Vi plays an important role in angiogenesis. In this review, the structure and mechanism of PRL and Vi as well as their possible mechanism and regulation in mammalian follicular development were reviewed, which can provide reference for exploring the regulatory mechanism of animal follicular development.

关 键 词：催乳素 卵泡发育 血管发生 血管抑制素 

分 类 号：S814.1[农业科学—畜牧学]