面向骨科植入应用的可降解锌基材料研究进展  

Research progress in biodegradable Zn-based materials for orthopedic applications

作　　者：孙疆 石章智 李亚庚 李相民 李危石[1,2,3] 王鲁宁 SUN Jiang;SHI Zhangzhi;LI Yageng;LI Xiangmin;LI Weishi;WANG Luning(Department of Orthopedic,Peking University Third Hospital,Beijing 100191,China;Engineering Research Center of Bone and Joint Precision Medicine,Beijing 100191,China;Beijing Key Laboratory of Spinal Disease Research,Beijing 100191,China;Beijing Advanced Innovation Center for Materials Genome Engineering,School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,China)

机构地区：[1]北京大学第三医院骨科,北京100191 [2]骨与关节精准医学工程研究中心,北京100191 [3]脊柱疾病研究北京市重点实验室,北京100191 [4]北京科技大学材料科学与工程学院北京材料基因工程高精尖创新中心,北京100083

出　　处：《材料工程》2022年第11期14-25,共12页Journal of Materials Engineering

基　　金：国家自然科学基金面上项目(5207010390);首都临床诊疗技术研究与转化应用项目(Z201100005520073);中央高校基本科研业务费(FRF-TP-19-022A3Z)。

摘　　要：近几年来,锌合金凭借其良好的生物相容性、促成骨活性以及在体内无害降解等优势,展现出作为骨科内植物材料的巨大潜力。本文介绍了纯锌的生理作用、降解速率以及力学性能等方面的特性,以上述指标与骨科临床需求存在的差距为引,以合金化元素为分类依据,阐述了目前研究人员通过改变材料的微观组织结构并触发相应的强化机制,以及利用添加元素的生理协同功能等方式改善锌基材料性能的现有成果。对医用锌基材料领域在标准制定和合金设计改进以及引入增材制造等新技术等方面进行了讨论,以期匹配多样化的临床诊疗需求。In recent years,zinc alloys have shown great potential as orthopedic plant materials because of their excellent biocompatibility,osteoinductive and biodegradation activities in vivo.The physiological function,degradation rate and mechanical properties of pure zinc were introduced in this review.Taking the gap between the above indicators and the clinical needs of orthopedics as the clue and the alloy elements as the classification basis,the existing achievements of researchers to improve the properties of zinc-based materials by changing the microstructure of materials and triggering the corresponding strengthening mechanism,and using the physiological synergistic function of added elements were expounded in this paper.The standard formulation,alloy design improvement and the introduction of new technologies such as additive manufacturing in the field of medical zinc based materials were discussed in order to meet the diversified needs of clinical diagnosis and treatment.

关 键 词：生物可降解 锌合金 骨科内植物 体内测试 合金设计 

分 类 号：R318[医药卫生—生物医学工程]