姜黄素衍生物9807的药效学研究  

Study on pharmacological activities of curcumin derivatives 9807

作　　者：郝志勇[1] 李燕[2] 陈晓光[2] 

机构地区：[1]中国协和医科大学中国医学科学院基础医学研究所,北京100005 [2]中国协和医科大学中国医学科学院药物研究所,北京100050

出　　处：《哈尔滨商业大学学报（自然科学版）》2002年第5期491-495,共5页Journal of Harbin University of Commerce：Natural Sciences Edition

摘　　要：采用鼠耳肿胀模型、细胞间隙连接通讯实验方法探讨其抗促癌作用 ;应用DNFB诱发的迟发型超敏反应及脾淋巴细胞转化实验观察 980 7的生物反应调节剂样作用 ;应用体外培养的细胞株检测980 7对细胞的杀伤作用及对动物移植性肿瘤H2 2、S180及W2 5 6的抑制作用。结果表明 980 7在 2 5、5 0mg/kg剂量下有明显抑制鼠耳肿胀的作用 ;10 μg/ml的 980 7可对抗TPA引起的细胞间隙传导减弱的现象 ;12 5、2 5、5 0mg/kg作用 8d后 ,经DNFB致敏的小鼠耳重增加 ,胸腺系数及脾系数均有所增高 ;无论有无ConA存在的条件下 ,980 7均可提高脾淋巴细胞转化率。对体外培养的肿瘤细胞 ,980 7有一定的杀伤作用 ,且对正常细胞的杀伤作用低于肿瘤细胞。对体内动物移植性肿瘤也表现出抑制其生长的作用 ,并有较好的量效关系。上述结果表明姜黄素衍生物 980 7有一定抗促癌。Anti-promotion effect of 9807 were studied by using the method of croton-oil induced auricular edema in mice and scrape-loading and dye transfer Experiment of 9807 on the reaction of mice against DNFB and the proliferation of spleen lymphocyte were conducted The effects of 9807 on transplantable tumors and the cells in ivtro were been also studied At 25 mg/kg and 50 mg/kg,9807 had the activity against inflammation resulting from stimulation of croton oil At 10 μg/ml,9807 could counteracted the inhibition of gap junction intercellular communication caused by TPA 9807 enhanced the reaction of mice ear skin,coefficient of spleen and thymus against DNFB 9807 could promoted the transformation of T lymphocyte In ivtro,the toxicity of normal cells were lower than that of cancer cells The results indicated that 9807 could inhibit the growth of transplantable tumors in a dose-dependent manner This suggests that 9807 has potent anti-promotion and tumor therapeutic activities and improve the immune system

关 键 词：姜黄素衍生物 9807 药效学 抗促癌作用 抗肿瘤 提高免疫力 中药 鼠耳肿胀模型 

分 类 号：R285.5[医药卫生—中药学]