神曲消食口服液与甘草锌联合治疗小儿厌食症对食量、体质量、血红蛋白及胃肠激素水平的影响  

Effects of the combination of Shentu Xiaoshi oral liquid and zinc licorice on food intake, body mass, hemoglobin and gastrointestinal hormone levels in the treatment of pediatric anorexia nervosa

作　　者：陈鲜 李磊[1] 王林[2] CHEN Xian;LI Lei;WANG Lin(Department of Pediatrics,Chengdu Second People's Hospital,Chengdu 610021,China;Department of Pediatrics,Chengdu Qingbaijiang District People's Hospital,Chengdu 610300,China)

机构地区：[1]成都市第二人民医院儿科,四川成都610021 [2]成都市青白江区人民医院儿科,四川成都610300

出　　处：《西部医学》2022年第11期1669-1672,1678,共5页Medical Journal of West China

基　　金：四川省妇幼保健医学会科研项目(2020ZD09)。

摘　　要：目的 探讨神曲消食口服液与甘草锌联合治疗小儿厌食症对食量、体质量、血红蛋白及胃肠激素水平的影响。方法 选取2020年1月~2020年12月成都市青白江区人民医院收治的厌食症患儿116例,按随机数字表法分为观察组和对照组,每组58例。对照组应用甘草锌治疗,观察组应用神曲消食口服液与甘草锌联合治疗,均治疗4周。比较两组临床疗效和不良反应发生情况,治疗前后食量、体质量、血红蛋白、胃动素(MOT)、胃泌素(GAS)及神经肽Y(NPY)水平变化情况。结果 重复测量方差分析显示时点效应、时点和组间交互效应可显著影响食量、体质量、血红蛋白水平变化,组间效应可显著影响食量、体质量水平变化;且观察组治疗后食量、体质量、血红蛋白升高程度较对照组明显,差异均有统计学意义(P<0.05)。重复测量方差分析显示时点效应、时点和组间交互效应、组间效应可显著影响MOT、GAS、NPY水平变化;且观察组治疗后MOT、GAS、NPY升高程度较对照组明显,差异均有统计学意义(P<0.05)。观察组临床总有效率(94.83%)显著高于对照组(81.03%),差异有统计学意义(P<0.05)。治疗4周期间,观察组出现1例轻微皮疹、1例腹泻,对照组出现1例浮肿,两组药物不良反应发生率分别为3.45%、1.72%,比较差异无统计学意义(P>0.05)。结论 神曲消食口服液与甘草锌联合治疗小儿厌食症疗效显著,可有效增加患儿食量、体质量,改善血红蛋白和胃肠激素水平,且安全性较高。Objective To investigate the effects of the combination of Shentu Xiaoshi oral liquid and zinc licorice on food intake, body mass, hemoglobin and gastrointestinal hormone levels in the treatment of pediatric anorexia nervosa. Methods One hundred and sixteen children with anorexia nervosa who were treated in Chengdu Qingbaijiang District People’s hospital from January 2020 to December 2020 were selected and divided into two groups by the random number table method: the control group(58 cases) was treated with zinc glycyrrhiza, and the observation group(58 cases) was treated with the combination of Shentu Xiaoshi oral liquid and zinc glycyrrhiza, both for 4 weeks. The clinical efficacy and the occurrence of adverse reactions were compared between the two groups, and the changes of food intake, body mass, hemoglobin, gastrin(MOT), gastrin(GAS) and neuropeptide Y(NPY) levels were also compared before and after treatment. Results Repeated-measures ANOVA showed that the point-in-time effect, point-in-time and between-group interaction effects significantly affected changes in food intake, body mass and hemoglobin levels, and between-group effects significantly affected changes in food intake and body mass levels;and the degree of increase in food intake, body mass and hemoglobin in the observation group was significantly higher than that in the control group after treatment, and the differences were statistically significant(P<0.05). Repeated-measures ANOVA showed that time-point effect, between-group effect, and time-point and between-group interaction effect could significantly affect the changes of MOT, GAS, and NPY levels, and between-group effect could significantly affect the changes of MOT, GAS, and NPY levels;and the increase of MOT, GAS, and NPY in the observation group after treatment was more significant than that in the control group, and the differences were statistically significant(P<0.05). The difference between the clinical efficacy of the observation group and the control group was significant, and

关 键 词：神曲消食口服液 甘草锌 小儿厌食症 食量 体质量 血红蛋白 胃肠激素 

分 类 号：R725.7[医药卫生—儿科]