血清同型半胱氨酸在非酒精性脂肪肝炎的诊断中的探索与应用  

Exploration and Application of Serum Homocysteine in the Diagnosis of Nonalcoholic Steatohepatitis

作　　者：王亚刚 黄融 林嘉裕 陈诚[3] 胡国信[4] WANG Ya-gang;HUANG Rong;LIN Jia-yu;CHEN Cheng;HU Guo-xin(Outpatient Department of Chronic Disease Prevention and Treatment Hospital,Shenzhen 518104,Guangdong Province,China;School of Mathematics,Sun Yat-sen University,Guangzhou 510006,Guangdong Province China;Digestive Internal Medicine,the Eighth Affiliated Hospital of Sun Yat-sen University,Shenzhen 518000,Guangdong Province,China;Department of Infectious Diseases,Shenzhen Hospital,Peking University,Shenzhen 518000,Guangdong Province,China)

机构地区：[1]广东省深圳市福田区慢性病防治院门诊部,广东深圳518104 [2]中山大学数学学院,广东广州510006 [3]中山大学附属第八医院消化内科,广东深圳518000 [4]北京大学深圳医院感染科,广东深圳518000

出　　处：《罕少疾病杂志》2022年第11期52-55,共4页Journal of Rare and Uncommon Diseases

基　　金：深圳市福田区卫生公益性科研项目(FTWS2020055)。

摘　　要：目的研究血清同型半胱氨酸水平与非酒精性脂肪肝炎的相关性,分析评价同型半胱氨酸与脂肪肝的相关性,并构建脂肪肝炎的临床诊断模型。方法选择2020至2021年在深圳市福田区医疗体进行体检的10871例体检者为研究对象,将研究对象分为脂肪肝组共和非脂肪肝组。通过分析体检者的检测数据,评价血清同型半胱氨酸水平对脂肪肝的诊断效能,并构建脂肪肝的诊断模型。结果HCY的脂肪肝组均高于非脂肪肝组,差异具有统计学意义(P<0.01)。进而构建非酒精性脂肪肝炎诊断模型的AUC值为0.779,当模型的Cut-off值为0.3951时,其诊断脂肪肝的灵敏度为75.2%,特异度为66.5%。结论本次研究建立的非酒精性脂肪肝炎诊断模型具有较好的诊断效能,具有一定的临床应用性。Objective To study the correlation between serum homocysteine level and nonalcoholic steatohepatitis,analyze and evaluate the correlation between homocysteine and steatohepatitis,and construct a clinical diagnostic model of steatohepatitis.Methods 10871 physical examinees who underwent physical examination in Futian District of Shenzhen from 2020 to 2021 were selected as the research objects.The research objects were divided into fatty liver group and non fatty liver group.By analyzing the test data of physical examinees,the diagnostic efficacy of serum homocysteine level in fatty liver was evaluated,and the diagnostic model of fatty liver was constructed.Results The fatty liver group of Hcy was significantly higher than that of non fatty liver group(P<0.01).Then the diagnostic model of nonalcoholic steatohepatitis was constructed.The AUC value of the model is 0.779.When the cut-off value of the model is 0.3951,the sensitivity and specificity for the diagnosis of fatty liver are 75.2%and 66.5%.Conclusion The diagnostic model of nonalcoholic steatohepatitis established in this study has good diagnostic efficacy and certain clinical applicability.

关 键 词：同型半胱氨酸 非酒精性脂肪肝 诊断模型 

分 类 号：R322.47[医药卫生—人体解剖和组织胚胎学]