可溶性sCD25、白细胞介素IL-2在登革热患者血清中变化及临床意义  

Changes and Clinical Significance of Soluble Scd25 and Interleukin-2 in Serum of Dengue Fever Patients

作　　者：林婉珍 LIN Wan-zhen(Laboratory of Lianjiang Center for Disease Control and prevention,Fuzhou 350500,Fujian Province,China)

机构地区：[1]连江县疾病预防控制中心检验科,福建福州350500

出　　处：《罕少疾病杂志》2022年第11期108-109,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的分析登革热患者血清中可溶性白细胞介素IL-2受体(sCD25)、白细胞介素IL-2的变化规律及临床意义。方法选取2004年1月至2020年12月6年期间送检我单位的登革热确诊患者血清52例为观察组,且同期取健康体检人员血清52例为对照组,分别检测血清中sCD25、IL-2,并分析各指标和疾病之间关系以及变化规律。结果观察组患者血清sCD25水平显著高于对照组、IL-2水平显著低于对照组,差异较大(P<0.05);患者发热时间超过5天血清sCD25水平均更高及IL-2水平更低,差异较大(P<0.05);出血性皮疹患者各指标水平均高于充血性皮疹患者,差异较大(P<0.05);肝功能正常患者各指标水平显著低于肝功能异常患者,差异较大(P<0.05)。结论登革热患者血清sCD25、IL-2水平和健康人员相比差异显著,研究认为两个指标均可用于登革热筛查,且合并肝功能异常、临床发热时间的长短、出血性皮疹患者各指标水平,可反应疾病的程度。Objective To analyze the changes and clinical significance of soluble interleukin IL-2 receptor(scd25)and interleukin IL-2 in serum of patients with dengue fever.Methods 52 sera from patients with dengue fever who were sent to our unit for examination from January 2004 to December 2020 were selected as the observation group,and 52 sera from healthy physical examinees were taken as the control group at the same time.The serum scd25 and IL-2 were detected respectively,and the relationship between each index and the disease was analyzed.Results The level of serum scd25 in the observation group was significantly higher than that in the control group,and the level of IL-2 was significantly lower than that in the control group(P<0.05);The level of serum scd25 was higher and the level of IL-2 was lower in patients with fever more than 5 days(P<0.05);The levels of all indexes in patients with hemorrhagic rash were higher than those in patients with congestive rash(P;The levels of various indexes in patients with normal liver function were significantly lower than those in patients with abnormal liver function(P<0.05).Conclusion The levels of serum scd25 and IL-2 in patients with dengue fever are significantly different from those in healthy people.The study shows that the two indicators can be used for dengue fever screening,and the level of indicators in patients with liver dysfunction,the length of clinical fever,and hemorrhagic rash can reflect the degree of the disease.

关 键 词：登革热患者 可溶性sCD25 白细胞介素IL-2 血清标本 

分 类 号：R373.33[医药卫生—病原生物学]