Kisspeptin调节肽参与多囊卵巢综合征的研究进展  

Research progress on kisspeptin regulatory peptide in polycystic ovary syndrome

作　　者：刘现娜 张宁[2] LIU Xianna;ZHANG Ning(Second Clinical Medical College,Binzhou Medical University,Yantai,Shandong 264003,China;Centerfor Reproductive Medicine,Yantai Yuhuangding Hospital,Yantai,Shandong 264000,China)

机构地区：[1]滨州医学院第二临床医学院,山东烟台264003 [2]烟台毓璜顶医院生殖医学科,山东烟台264000

出　　处：《安徽医药》2022年第12期2341-2344,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：多囊卵巢综合征(PCOS)是常见的内分泌及代谢性疾病,其发病机制尚不清楚,下丘脑-垂体-卵巢轴(HPO轴)功能紊乱是PCOS发生的主要原因之一。Kisspeptin调节肽是下丘脑中的一种调节肽,可以和下丘脑内GPR54受体结合,促进下丘脑促性腺激素释放激素(GnRH)及促黄体生成素(LH)的分泌,造成HPO轴功能紊乱;Kisspeptin调节肽不仅存在于下丘脑中枢调控HPO轴,还可以在卵巢局部发挥作用,影响卵巢微环境,阻碍卵泡的成熟,调控PCOS的发生和发展。PCOS病人不仅存在生殖内分泌的异常,大多还存在糖脂代谢紊乱,Kisspeptin调节肽可能通过生殖内分泌及能量代谢的双重调节作用参与PCOS的发生。该研究将对Kisspeptin调节肽影响PCOS病人生殖内分泌、能量代谢及其临床应用进行综述,为进一步了解Kisspeptin调节肽和PCOS的关系提供参考。Polycystic ovary syndrome(PCOS) is a common endocrine and metabolic disease,and its pathogenesis is still unclear.Dysfunction of the hypothalamic pituitary ovary(HPO) axis is one of the main causes of PCOS.Kisspeptin regulatory peptide is a regulatory peptide in the hypothalamus that can combine with the GPR54 receptor and promote the secretion of gonadotropin-releasing hormone(GnRH) and luteinizing hormone(LH) in the hypothalamus,causing dysfunction of the HPO axis.Kisspeptin regulatory peptides not only exist in the hypothalamic center to regulate the HPO axis,but also play a role in the local ovary,affect the ovarian microenvironment,hinder the maturation of follicles,and regulate the occurrence and development of PCOS.PC OS patients not only have abnormal reproductive endocrine function,but also have disorders of glucose and lipid metabolism.Kisspeptin regulatory peptide may participate in the occurrence of PCOS through the dual regulation of reproductive endocrine and energy metabolism.This study will review the influence of kisspeptin regulatory peptide on the reproductive endocrine system,energy metabolism and clinical application of PCOS patients,and provide a reference for further understanding the relationship between kisspeptin regulatory peptide and PCOS.

关 键 词：多囊卵巢综合征 Kisspeptin调节肽 下丘脑-垂体-卵巢轴 胰岛素抵抗 促性腺素释放激素 能量代谢 综述 

分 类 号：R711.75[医药卫生—妇产科学]