重症肺炎支原体肺炎老年人血清纤维蛋白原、血小板反应蛋白-1表达及其与预后的相关性  

The expression of FIB and TSP-1 in elderly patients with severe mycoplasma pneumoniae pneumonia and their correlation with prognosis

作　　者：洪丽明 田秘 李乐辉 吴国平[1] HONG Liming;TIAN Mi;LI Lehui;WU Guoping(Emergency ICU,The First Affiliated Hospital of Hainan Medical College,Haikou,Hainan 570102,China)

机构地区：[1]海南医学院第一附属医院急诊ICU,海南海口570102

出　　处：《安徽医药》2022年第12期2466-2469,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的 检测重症肺炎支原体肺炎(MPP)病人血清纤维蛋白原(FIB)和血小板反应蛋白-1(TSP-1)的表达情况,并探究其表达水平与MPP病人预后的相关性。方法 选取2017年3月至2018年12月在海南医学院第一附属医院收治的MPP老年人89例作为研究对象,其中重症MPP 46例作为重症组,轻症MPP 43例作为对照组。采用酶联免疫吸附测定(ELISA)检测各组研究对象血清FIB、TSP-1的表达水平;通过受试者操作特征曲线(ROC曲线)评估血清FIB、TSP-1表达水平对重症MPP的诊断价值;分析病人预后不良情况发生率;并采用logistic回归分析老年人发生预后不良的相关影响因素。结果 重症组血清FIB、TSP-1表达水平分别为(4.93±1.16)g/L、(375.42±34.13)μg/L,显著高于对照组的(3.85±0.97)g/L、(316.71±23.05)μg/L(P<0.05)。ROC结果显示,血清FIB和TSP-1单独及联合诊断重症MPP的曲线下面积(AUC)分别为0.796、0.900、0.926,血清FIB联合TSP-1诊断重症MPP的灵敏度和特异度分别为84.82%、90.65%。高FIB组、高TSP-1组老年人病人预后不良发生率分别为54.55%(12/22)、55.00%(11/20),显著高于低FIB组的16.67%(4/24)及低TSP-1组的19.23%(5/26)(P<0.05)。logistic回归分析显示,血清FIB、TSP-1表达水平是影响重症MPP病人发生预后不良的独立危险因素(均P<0.05)。结论 FIB和TSP-1在重症MPP病人血清中的表达水平明显升高,且其高表达与病人预后不良有关,均可作为重症MPP的早期诊断及预后评估的潜在生物学指标。Objective To detect the expression of serum fibrinogen(FIB) and thrombospondin-1(TSP-1) in patients with severe Mycoplasma pneumoniae pneumonia(MPP) and to explore the correlation between their expression level and the prognosis of MPP patients.Methods A total of 89 cases of elderly MPP patients admitted to the First Affiliated Hospital of Hainan Medical College from March 2017 to December 2018 were selected as study subjects,including 46 cases of severe MPP as the severe group and 43 cases of mild MPP as the control group.Enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of serum FIB and TSP-1 in each group;the receiver operating characteristic(ROC) curve was used to assess the diagnostic values of serum FIB and TSP-1 expression levels in severe MPP;the incidence of poor prognosis in patients was analyzed;and logistic regression was used to analyze the influencing factors related to the occurrence of poor prognosis in elderly individuals.Results The expression levels of serum FIB and TSP-1 in the severe group were(4.93±1.16) g/L and(375.42±34.13) μg/L,respectively,which were significantly higher than those in the control group [(3.85±0.97) g/L and(316.71±23.05) μg/L](P<0.05).ROC results showed that the area under the curve(AUC) of serum FIB and TSP-1 alone and in combination were 0.796,0.900 and 0.926,respectively,and the sensitivity and specificity of serum FIB in combination with TSP-1 for the diagnosis of severe MPP were 84.82% and 90.65%,respectively.The incidence of poor prognosis in elderly patients in the high FIB group and high TSP-1 group was 54.55%(12/22) and 55.00%(11/20),respectively,which was significantly higher than those in the low FIB group [16.67%(4/24)] and the low TSP-1 group [19.23%(5/26)](P<0.05).Logistic regression analysis showed that the levels of serum FIB and TSP-1 were independent risk factors for the development of poor prognosis in severe MPP patients(P<0.05).Conclusion The expression levels of FIB and TSP-1 in the serum of severe MPP patients were signifi

关 键 词：肺炎 支原体 纤维蛋白原 血小板反应蛋白-1 预后 老年人 

分 类 号：R563.1[医药卫生—呼吸系统]